Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Optic nerve injury
ADR ID BADD_A03181
ADR Hierarchy
06      Eye disorders
06.11      Ocular injuries
06.11.02      Optic pathway injuries
06.11.02.001      Optic nerve injury
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.16      Cranial nerve injuries
12.01.16.001      Optic nerve injury
17      Nervous system disorders
17.04      Cranial nerve disorders (excl neoplasms)
17.04.05      Optic nerve disorders NEC
17.04.05.008      Optic nerve injury
Description Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect. [MeSH]
MedDRA Code 10030938
MeSH ID D020221
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Injury to optic chiasm | Injury to optic nerve and pathways | Injury to optic nerve and pathways, unspecified | Injury to unspecified optic nerve and pathways | Optic nerve injury | Optic nerve injury NOS | Optic nerve damage | Optic Nerve Injuries | Injuries, Optic Nerve | Injury, Optic Nerve | Nerve Injuries, Optic | Nerve Injury, Optic | Optic Nerve Injury | Optic Neuropathy, Traumatic | Neuropathies, Traumatic Optic | Neuropathy, Traumatic Optic | Optic Neuropathies, Traumatic | Traumatic Optic Neuropathies | Traumatic Optic Neuropathy | Trauma, Second Cranial Nerve | Cranial Nerve II Injuries | Second Cranial Nerve Injuries | Optic Nerve Trauma | Nerve Trauma, Optic | Nerve Traumas, Optic | Optic Nerve Traumas | Trauma, Optic Nerve | Traumas, Optic Nerve | Second Cranial Nerve Trauma | Optic Nerve Contusion | Contusion, Optic Nerve | Contusions, Optic Nerve | Nerve Contusion, Optic | Nerve Contusions, Optic | Optic Nerve Contusions | Optic Nerve Transection | Nerve Transection, Optic | Nerve Transections, Optic | Optic Nerve Transections | Transection, Optic Nerve | Transections, Optic Nerve | Optic Nerve Avulsion | Avulsion, Optic Nerve | Avulsions, Optic Nerve | Nerve Avulsion, Optic | Nerve Avulsions, Optic | Optic Nerve Avulsions
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00115Amiodarone0.002976%
BADD_D00667Difluprednate--
BADD_D00809Escitalopram0.000190%
BADD_D00929Fluorometholone--
BADD_D00930Fluorometholone acetate--
BADD_D01281Levonorgestrel0.005211%
BADD_D01324Loteprednol etabonate--
BADD_D01834Prednisone--
BADD_D01946Rimexolone--
BADD_D02355Vigabatrin0.000507%
BADD_D02464Fingolimod0.003474%
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