Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cutis laxa
ADR ID BADD_A01134
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.06      Connective tissue disorders (excl congenital)
15.06.01      Connective tissue disorders NEC
15.06.01.007      Cutis laxa
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.02      Connective tissue disorders
23.03.02.009      Cutis laxa
Description A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed) [MeSH]
MedDRA Code 10011692
MeSH ID D003483; D003483; D003483
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cutis laxa | Dermatochalasis | Dermatolysis | Skin laxity | Cutis Laxa | Dermatomegaly | Dermatolyses
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Collagen alpha-1(I) chainP02452Not Available
ElastinP15502Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000303%
BADD_D00354Captopril0.002235%
BADD_D01555Nepafenac--
BADD_D01709Penicillamine--
BADD_D01834Prednisone0.000040%
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