Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Captopril
Drug ID BADD_D00354
Description Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Indications and Usage For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
Marketing Status Prescription; Discontinued
ATC Code C09AA01
DrugBank ID DB01197
KEGG ID D00251
MeSH ID D002216
PubChem ID 44093
TTD Drug ID D0I0EG
NDC Product Code 69292-526; 0781-8052; 51552-1072; 51407-602; 27241-162; 71335-1918; 53296-0031; 60687-315; 57721-905; 31722-143; 63673-0457; 53069-0150; 50090-4296; 0143-1171; 63629-8729; 57721-903; 71335-0826; 0904-5045; 55488-0600; 27241-163; 31722-141; 51927-0137; 63629-1338; 0143-1173; 31722-142; 0143-1172; 0781-8080; 60687-304; 51407-603; 0904-5047; 63629-8727; 0904-5046; 0904-7105; 27241-161; 0143-1174; 70518-3307; 51407-600; 63629-8728; 0781-8075; 55289-344; 69292-528; 69292-524; 0904-7106; 57721-904; 63629-8730; 31722-144; 27241-160; 57721-902; 69292-522; 51407-601; 0781-8061
Synonyms Captopril | (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline | Lopirin | SQ-14,534 | SQ 14,534 | SQ14,534 | SQ-14534 | SQ 14534 | SQ14534 | Capoten | SQ-14,225 | SQ 14,225 | SQ14,225 | SQ-14225 | SQ 14225 | SQ14225
Chemical Information
Molecular Formula C9H15NO3S
CAS Registry Number 62571-86-2
SMILES CC(CS)C(=O)N1CCCC1C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionSolute carrier family 2, facilitated glucose transporter member 2P11168Not Available9090458; 8866414; 12939321
Adverse drug reactionSolute carrier family 2, facilitated glucose transporter member 1P11166T894589090458; 8866414; 12939321; 9096453
Blood pressure decreasedKininogen-1P01042T307313901042; 3544715; 6315269; 6283904
Blood pressure decreasedKallikrein-10O43240Not Available3901042; 3544715; 6315269
Blood pressure decreasedAngiotensin-converting enzymeP12821T8257716395257; 16138565; 9270093; 10535720; 9726242; 10620209; 10880412; 8986921; 10999650
CoughB2 bradykinin receptorP30411T2371410904024; 12522467; 11699055; 15894833
LeukopeniaLysozyme CP61626T105866764221; 7184960; 7055639; 6991024; 1151072; 874088; 6490097; 6295781; 3293542
LeukopeniaBeta-glucuronidaseP08236T964136764221; 7184960; 7055639; 6991024; 1151072; 874088; 6490097; 6295781; 3293542
ProteinuriaAngiotensin-converting enzyme 2Q9BYF1T278893540694; 6761860; 3281046; 6993700
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.002235%
Acidosis14.01.03.002--
Acute respiratory failure22.02.06.001; 14.01.04.0040.002235%Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.0010.002235%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000875%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema10.01.05.009; 23.04.01.0010.017883%Not Available
Anuria20.01.03.002--Not Available
Aphthous ulcer07.05.06.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.002235%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blister23.03.01.001; 12.01.06.002--Not Available
Blood potassium increased13.11.01.011--Not Available
Blood pressure decreased13.14.03.0020.003353%Not Available
Blood pressure increased13.14.03.0050.004471%Not Available
Blood pressure normal13.14.03.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.0010.002235%
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Cholestasis09.01.01.001--Not Available
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