Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Captopril
Drug ID BADD_D00354
Description Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Indications and Usage For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy.
Marketing Status approved
ATC Code C09AA01
DrugBank ID DB01197
KEGG ID D00251
MeSH ID D002216
PubChem ID 44093
TTD Drug ID D0I0EG
NDC Product Code 27241-162; 31722-141; 31722-142; 0143-1171; 63629-8728; 69292-526; 53296-0031; 31722-144; 0143-1174; 60687-304; 63629-1338; 63629-8730; 0781-8061; 0904-7105; 63629-8729; 70518-3307; 71335-1918; 51552-1072; 51927-0137; 27241-160; 27241-161; 43547-363; 63629-8727; 69292-522; 71335-0826; 0781-8052; 53069-0150; 31722-143; 27241-163; 51407-601; 51407-602; 51407-603; 43547-366; 55289-344; 0781-8080; 55488-0600; 43547-364; 0781-8075; 0143-1172; 0143-1173; 43547-365; 50090-5964; 51407-600; 60687-315; 69292-524; 69292-528; 0904-7106
UNII 9G64RSX1XD
Synonyms Captopril | (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline | Lopirin | SQ-14,534 | SQ 14,534 | SQ14,534 | SQ-14534 | SQ 14534 | SQ14534 | Capoten | SQ-14,225 | SQ 14,225 | SQ14,225 | SQ-14225 | SQ 14225 | SQ14225
Chemical Information
Molecular Formula C9H15NO3S
CAS Registry Number 62571-86-2
SMILES CC(CS)C(=O)N1CCCC1C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acidosis14.01.03.002--
Acute myocardial infarction24.04.04.001; 02.02.02.0010.000488%Not Available
Acute respiratory failure22.02.06.001; 14.01.04.0040.000732%Not Available
Ageusia07.14.03.003; 17.02.07.001--Not Available
Agitation19.06.02.001; 17.02.05.0120.000488%
Agranulocytosis01.02.03.001--Not Available
Alopecia23.02.02.001--
Anaemia01.03.02.0010.000975%
Anaphylactic shock24.06.02.004; 10.01.07.0020.000732%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.0090.004146%Not Available
Anuria20.01.03.002--Not Available
Aphthous ulcer07.05.06.002--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.000732%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Blister12.01.06.002; 23.03.01.001--Not Available
Blood potassium increased13.11.01.011--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood pressure normal13.14.03.010--Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.0020.000732%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000488%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000732%
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.0110.000732%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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