Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nepafenac
Drug ID BADD_D01555
Description Nepafenac is a non-steroidal anti-inflammatory prodrug (NSAID) usually sold as a prescription eye drop. It is used to treat pain and inflammation associated with cataract surgery.
Indications and Usage For the treatment of pain and inflammation associated with cataract surgery.
Marketing Status Prescription
ATC Code S01BC10
DrugBank ID DB06802
KEGG ID D05143
MeSH ID C414203
PubChem ID 151075
TTD Drug ID D02IHW
NDC Product Code 69988-0005; 0078-0743; 53296-0099; 64181-0019; 42571-353; 73309-311; 0065-0002; 58567-104
Synonyms nepafenac | 2-amino-3-benzoylbenzeneacetamide | Nevanac
Chemical Information
Molecular Formula C15H14N2O2
CAS Registry Number 78281-72-8
SMILES C1=CC=C(C=C1)C(=O)C2=CC=CC(=C2N)CC(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal labour18.07.02.001--Not Available
Abnormal sensation in eye06.01.01.0010.001348%Not Available
Arrhythmia02.03.02.0010.001348%Not Available
Arthritis15.01.01.001--
Atrial fibrillation02.03.03.0020.001348%
Bleeding time prolonged13.01.02.002--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood pressure increased13.14.03.0050.002022%Not Available
Cataract06.06.01.001--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.001348%Not Available
Conjunctival oedema06.04.01.0010.002695%Not Available
Conjunctivitis allergic10.01.04.002; 06.04.01.003--Not Available
Corneal deposits06.06.03.002--Not Available
Corneal epithelium defect06.06.03.0120.003369%Not Available
Corneal erosion06.06.03.0030.004043%Not Available
Corneal infiltrates06.08.01.0020.002022%Not Available
Corneal oedema06.04.02.0010.001348%Not Available
Corneal opacity06.06.03.0050.002695%Not Available
Corneal perforation12.01.04.003; 06.06.03.0060.000703%Not Available
Corneal scar12.01.04.015; 06.06.03.015--Not Available
Cutis laxa23.03.02.009; 15.06.01.007--Not Available
Dermatitis atopic10.01.04.004; 23.03.04.016--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.0010.003369%
Dry mouth07.06.01.002--
Endophthalmitis11.01.06.003; 06.04.05.009--
Erythema23.03.06.0010.002695%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.0030.001348%Not Available
Eye discharge06.04.05.0010.005391%Not Available
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