Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fingolimod
Drug ID BADD_D02464
Description Multiple sclerosis or MS is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects.[A176474] Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially approved by the FDA in 2010.[L12651] Fingolimod is currently being studied for the treatment of COVID-19, the disease caused by infection with the SARS-CoV-2 virus. Phase 2 clinical trials are currently underway and completion is expected in July 2020.[L12654]
Indications and Usage Fingolimod is a sphingosine 1-phosphate receptor modulator indicated for the treatment of patients with relapsing forms of multiple sclerosis to reduce the frequency of clinical exacerbations and to delay the accumulation of physical disability.
Marketing Status Not Available
ATC Code L04AA27
DrugBank ID DB08868
KEGG ID D10001
MeSH ID D000068876
PubChem ID 107970
TTD Drug ID D07UHS
NDC Product Code 54893-0026; 65035-201
Synonyms Fingolimod Hydrochloride | 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride | FTY-720 | FTY 720 | FTY720 | Gilenya | Gilenia | Fingolimod
Chemical Information
Molecular Formula C19H33NO2
CAS Registry Number 162359-55-9
SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchospasm22.03.01.004; 10.01.03.012--
Bruxism19.11.03.001; 07.01.06.0080.002316%Not Available
Bundle branch block02.03.01.0090.002895%Not Available
Bundle branch block left02.03.01.0070.005790%Not Available
Bundle branch block right02.03.01.0110.012738%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.042845%Not Available
Bursitis15.04.01.0010.004053%Not Available
C-reactive protein increased13.09.01.0070.022581%Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.009--Not Available
Calculus bladder20.04.02.0020.001737%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.0010.004053%Not Available
Cardiac tamponade02.06.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.001--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.001--Not Available
Carpal tunnel syndrome17.09.02.0010.013317%Not Available
Cataract06.06.01.0010.027213%
Cataract cortical06.06.01.0040.001158%Not Available
Cataract nuclear06.06.01.0050.002316%Not Available
CD4 lymphocytes decreased13.01.06.0160.028371%
Cellulitis23.09.01.001; 11.02.01.0010.019107%Not Available
Cerebellar ataxia17.02.02.013; 08.01.02.0060.001737%Not Available
Cerebellar syndrome17.02.02.0020.006369%Not Available
Cerebral atrophy17.11.01.0010.007527%Not Available
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