Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status approved
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 72865-150; 72865-151; 72865-152; 42291-459; 65862-832; 16714-080; 42291-461; 67877-504; 68180-228; 42543-962; 47335-600; 51407-297; 63629-8765; 63629-8764; 63629-9607; 64380-885; 67877-503; 69097-410; 69097-412; 47335-380; 50268-153; 51407-296; 76282-674; 76282-675; 16729-440; 16729-441; 31722-104; 65162-155; 65162-213; 67877-505; 42291-460; 42543-961; 43598-368; 65162-157; 65862-831; 69097-411; 43598-369; 63629-8763; 63629-9606; 63629-9608; 65862-833; 68180-226; 31722-103; 47335-379; 60687-525; 64380-883; 68180-227; 76282-676; 0904-7067; 31722-105; 43598-367; 64380-884; 16729-442; 42543-963; 51407-295
UNII UAZ6V7728S
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gallbladder disorder09.03.02.0010.002697%Not Available
Gastric ulcer07.04.03.0020.001564%
Gastritis erosive07.04.03.0030.000782%Not Available
Gastrooesophageal reflux disease07.02.02.0030.018060%
Gastrointestinal disorder07.11.01.0010.122550%Not Available
Gastrointestinal pain07.01.05.0050.003987%
Goitre14.11.01.008; 05.02.01.0010.000391%Not Available
Hernia08.01.04.0010.003635%Not Available
Hypercalcaemia14.04.01.003; 05.04.01.0020.014620%
Hyperchlorhydria07.11.03.0010.000860%Not Available
Hypermagnesaemia14.04.02.0020.000391%
Hyperparathyroidism14.04.01.020; 05.04.01.0010.002424%
Hyperparathyroidism primary14.04.01.021; 05.04.01.0050.000782%Not Available
Hyperparathyroidism secondary20.01.01.006; 05.04.01.004; 14.04.01.0220.000860%Not Available
Hyperphosphataemia14.04.03.0070.001564%
Hypertension24.08.02.0010.046792%
Hypervolaemia02.05.04.019; 14.05.06.0030.002619%Not Available
Hypoaesthesia17.02.06.023; 23.03.03.0810.078221%Not Available
Hypoalbuminaemia14.10.01.002; 09.01.02.0030.000977%
Hypocalcaemia14.04.01.0040.058245%
Hypochloraemia14.05.08.0030.000391%Not Available
Hypoparathyroidism14.04.01.007; 05.04.02.001; 12.02.15.0010.000586%
Hypoproteinaemia14.10.01.003; 09.01.02.0040.000782%Not Available
Hypotension24.06.03.0020.140845%
Impaired gastric emptying07.02.02.0040.000782%
Impaired healing08.03.02.001--Not Available
Intracranial aneurysm24.02.04.001; 17.08.06.0010.000391%Not Available
Kyphosis15.10.04.0020.000391%
Lip discolouration07.05.05.0090.001329%Not Available
Malaise08.01.01.0030.386179%
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