Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Colesevelam
Drug ID BADD_D02431
Description Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
Indications and Usage For use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa).
Marketing Status Not Available
ATC Code C10AC04
DrugBank ID DB00930
KEGG ID D07743
MeSH ID D000069472
PubChem ID 160051
TTD Drug ID D01YVT
NDC Product Code 70771-1368; 68382-619
Synonyms Colesevelam Hydrochloride | Hydrochloride, Colesevelam | Colesevelam HCl | HCl, Colesevelam | CholestaGel | Welchol | Colesevelam | GT 31104 | 31104, GT | GT-31104 | GT31-104 | GT31 104 | GT31104
Chemical Information
Molecular Formula C31H67Cl3N4O
CAS Registry Number 182815-44-7
SMILES CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C.C=CCN.C1C(O1)CCl.Cl.[Cl-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspepsia07.01.02.0010.005497%
Dysphagia07.01.06.0030.009772%
Dyspnoea22.02.01.004; 02.01.03.002--
Eructation07.01.02.0030.001832%
Faeces discoloured07.01.03.0020.002443%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.001832%Not Available
Flatulence07.01.04.0020.003664%
Gastrooesophageal reflux disease07.02.02.0030.002443%
Gastrointestinal disorder07.11.01.0010.001832%Not Available
Glaucoma06.03.01.0020.001221%
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.0040.001221%
Hypertension24.08.02.0010.002443%
Influenza22.07.02.001; 11.05.03.0010.001221%Not Available
Influenza like illness08.01.03.0100.001832%
Insomnia17.15.03.002; 19.02.01.0020.001832%
Intestinal obstruction07.13.01.0020.001832%Not Available
Laryngitis22.07.03.001; 11.01.13.0010.001221%
Lung disorder22.02.07.0010.001221%Not Available
Lymphadenopathy01.09.01.0020.001221%Not Available
Malaise08.01.01.0030.003664%
Muscle spasms15.05.03.0040.004886%
Myalgia15.05.02.0010.003664%
Nausea07.01.07.0010.009161%
Neck pain15.03.04.0090.001832%
Oesophageal obstruction07.13.02.0020.002443%
Pain08.01.08.0040.003054%
Pain in extremity15.03.04.0100.001832%
Pancreatitis07.18.01.0010.004275%
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