Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vitamin k1
Drug ID BADD_D02410
Description Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme γ-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259] It is indicated in the treatment of coagulation disorders due to faulty formation of coagulation factors II, VII, IX, and X caused by deficiency or interference in the activity of vitamin K.[L33319] Phylloquinone has been synthesized since at least 1939,[A234384] and was approved by the FDA prior to 1955.[L33389]
Indications and Usage Not Available
Marketing Status Not Available
ATC Code B02BA01
DrugBank ID DB01022
KEGG ID D00148
MeSH ID D010837
PubChem ID 5284607
TTD Drug ID D00FSV
NDC Product Code 51552-1063
Synonyms Vitamin K 1 | Phytonadione | Vitamin K1 | Phytomenadione | Phylloquinone | Phyllohydroquinone | Aquamephyton | Konakion
Chemical Information
Molecular Formula C31H46O2
CAS Registry Number 79083-00-4
SMILES CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.016067%
Acute myocardial infarction24.04.04.001; 02.02.02.0010.021422%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.0010.021422%
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.010711%Not Available
Cardiac arrest02.03.04.0010.004191%
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.005588%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.010711%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.016067%
Chills15.05.03.016; 08.01.09.0010.010711%
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.010711%
Death08.04.01.001--
Drug hypersensitivity10.01.01.0010.010711%Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.037489%
Erythema23.03.06.0010.004191%Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.010711%
Heart rate increased13.14.04.0020.010711%Not Available
Hemiparesis17.01.04.0010.010711%
Hyperhidrosis23.02.03.004; 08.01.03.0280.010711%
Hypersensitivity10.01.03.0030.010711%
Hypertension24.08.02.0010.010711%
Hypokalaemia14.05.03.0020.010711%
Hypotension24.06.03.0020.037489%
Hypoxia22.02.02.0030.021422%
International normalised ratio abnormal13.01.02.0290.010711%Not Available
Myocardial infarction24.04.04.009; 02.02.02.0070.002794%
Oxygen saturation decreased13.02.01.0040.010711%Not Available
Palpitations02.01.02.0030.010711%
Pruritus23.03.12.0010.010711%
Pulmonary embolism22.06.02.001; 24.01.06.0010.005588%Not Available
Pulse absent13.14.04.0050.016067%Not Available
The 1th Page    1 2    Next   Last    Total 2 Pages