Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Zolpidem
Drug ID BADD_D02394
Description Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of sleep, and decreases the number of awakenings during sleep in patients with temporary (transient) insomnia. It is available in both immediate acting and extended release forms [FDA label], [F3802]. Its tolerability profile is favorable when administered according to the manufacturer’s instructions, with a low risk of drug withdrawal, drug dependence, and drug tolerance [A175426]. In addition, zolpidem improves sleep quality in patients suffering from chronic insomnia and can show mild muscle relaxant properties [L5584]. Research also shows that zolpidem is rapid and effective in restoring brain function for patients in a vegetative state following brain injury. This drug has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury [L5584], [A175444].
Indications and Usage For the short-term treatment of insomnia.
Marketing Status Prescription; Discontinued
ATC Code N05CF02
DrugBank ID DB00425
KEGG ID D08690
MeSH ID D000077334
PubChem ID 5732
TTD Drug ID D0T1WN
NDC Product Code Not Available
Synonyms Zolpidem | Imidazo(1,2-a)pyridine-3-acetamide, N,N,6-trimethyl-2-(4-methylphenyl)- | SL 80.0750 | SL-800750-23-N | SL 800750 23 N | Zolirin | Zolpi-Lich | Zolpi Lich | Zolpidem 1A Pharma | Zolpidem AbZ | Zolpidem Tartrate | N,N,6-Trimethyl-2-(4-methylphenyl)imidazo(1,2a)pyridine-3-acetamide hemitartrate | Zolpidem Hemitartrate | Zolpinox | Zolpimist | Ambien | Amsic | Bikalm | Stilnoct | Stilnox | Dalparan | Zodormdura | Zoldem
Chemical Information
Molecular Formula C19H21N3O
CAS Registry Number 82626-48-0
SMILES CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness postural17.02.05.004; 02.01.02.005; 24.06.02.0080.000109%Not Available
Drooling17.02.05.0050.000109%Not Available
Drug abuse19.07.02.0100.004067%Not Available
Drug dependence19.07.02.0090.010266%Not Available
Drug eruption08.01.06.015; 23.03.05.001; 10.01.01.005--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Drug interaction08.06.03.001--Not Available
Drug withdrawal convulsions17.12.03.016; 08.06.02.0030.000543%Not Available
Drug withdrawal syndrome19.07.02.011; 08.06.02.0040.002553%Not Available
Dry eye06.08.02.0010.000163%
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dry throat22.02.05.004; 07.06.01.005--Not Available
Dysarthria17.02.08.001; 19.19.03.0010.000923%
Dysgeusia17.02.07.003; 07.14.03.001--
Dyskinesia17.01.02.0060.000978%
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Eclampsia17.12.03.012; 24.08.07.001; 20.01.08.001; 18.02.03.0010.000326%Not Available
Eczema23.03.04.0060.000543%
Electrocardiogram QT prolonged13.14.05.004--
Emotional disorder19.04.02.005--Not Available
Enteritis07.08.03.002--
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
The 5th Page    First    Pre   5 6 7 8 9    Next   Last    Total 20 Pages