Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.[L9821, L15571]
Marketing Status approved
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0781-5667; 60715-1700; 65372-1175; 27241-063; 39822-1077; 43386-088; 0378-1640; 66039-951; 70966-0030; 47781-466; 0049-4190; 55111-099; 58032-2007; 66039-876; 43386-038; 51079-164; 0049-3190; 64980-274; 64980-275; 65862-891; 68462-572; 70594-067; 70710-1247; 60687-273; 0378-1626; 65841-830; 72572-875; 68554-0111; 75945-102; 16714-199; 43547-378; 59762-0936; 63739-008; 65162-913; 65841-831; 0904-6596; 65862-916; 71052-149; 40032-038; 43386-089; 50268-803; 0049-3180; 68083-321; 71288-027; 72578-062; 14501-0014; 52562-001; 27241-062; 43547-377; 51552-1524; 16714-198; 59762-0934; 60687-294; 65219-190; 65862-892; 70771-1413; 72843-441; 0781-5668; 63126-911; 0049-3170; 70436-029; 72578-063; 0781-3416; 0904-7024; 51552-1573; 53296-0081; 64220-140; 65015-801; 73223-005; 51079-165; 63629-8734; 0049-3160; 68462-573; 72266-131; 51407-133; 55150-321; 59762-0935
UNII JFU09I87TR
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Poor quality sleep19.02.05.005; 17.15.04.0020.008713%Not Available
Metamorphopsia17.17.01.020; 06.02.06.0140.011617%Not Available
Solar lentigo23.05.01.0130.024396%Not Available
Bone marrow failure01.03.03.005--
Cytopenia01.03.03.0120.008713%Not Available
Mixed liver injury09.01.07.0150.008713%Not Available
Treatment failure08.06.01.0170.206783%Not Available
Liver injury12.01.17.012; 09.01.07.0220.066798%Not Available
Organising pneumonia22.01.02.0080.005809%Not Available
Oral disorder07.05.01.0050.012779%Not Available
Skin mass23.07.04.0140.005809%Not Available
Brain injury17.11.01.003; 19.07.03.0070.005809%Not Available
Traumatic liver injury12.01.17.027; 09.01.08.010--Not Available
Hypertransaminasaemia09.01.02.0050.029043%Not Available
Oropharyngeal discomfort22.12.03.015; 07.05.05.008--Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.004--
Acute kidney injury20.01.03.016--
Hypoxic-ischaemic encephalopathy24.04.06.021; 22.02.02.011; 17.13.02.0060.005809%Not Available
Resting tremor17.01.06.0080.008713%Not Available
Drug-induced liver injury09.01.07.023; 12.03.01.0440.142309%Not Available
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.059247%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.078415%
Anal incontinence17.05.01.021; 07.01.06.0290.005809%
Liver function test increased13.03.04.031--Not Available
Depersonalisation/derealisation disorder19.14.01.004--Not Available
Cardiac failure chronic02.05.01.0090.005809%Not Available
Concomitant disease aggravated08.01.03.0630.005809%Not Available
Dermatitis exfoliative generalised23.03.07.002; 10.01.01.0290.017426%Not Available
Enthesopathy15.07.01.0110.027300%Not Available
Jugular vein thrombosis24.01.02.0070.011617%Not Available
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