Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, cadidemia, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.[L9821, L15571]
Marketing Status approved
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0781-5667; 60715-1700; 65372-1175; 27241-063; 39822-1077; 43386-088; 0378-1640; 66039-951; 70966-0030; 47781-466; 0049-4190; 55111-099; 58032-2007; 66039-876; 43386-038; 51079-164; 0049-3190; 64980-274; 64980-275; 65862-891; 68462-572; 70594-067; 70710-1247; 60687-273; 0378-1626; 65841-830; 72572-875; 68554-0111; 75945-102; 16714-199; 43547-378; 59762-0936; 63739-008; 65162-913; 65841-831; 0904-6596; 65862-916; 71052-149; 40032-038; 43386-089; 50268-803; 0049-3180; 68083-321; 71288-027; 72578-062; 14501-0014; 52562-001; 27241-062; 43547-377; 51552-1524; 16714-198; 59762-0934; 60687-294; 65219-190; 65862-892; 70771-1413; 72843-441; 0781-5668; 63126-911; 0049-3170; 70436-029; 72578-063; 0781-3416; 0904-7024; 51552-1573; 53296-0081; 64220-140; 65015-801; 73223-005; 51079-165; 63629-8734; 0049-3160; 68462-573; 72266-131; 51407-133; 55150-321; 59762-0935
UNII JFU09I87TR
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pyrexia08.05.02.0030.197490%
Rash23.03.13.001--Not Available
Rash macular23.03.13.0030.008713%Not Available
Rash maculo-papular23.03.13.0040.020330%
Rash papular23.03.13.017--Not Available
Raynaud's phenomenon24.04.03.0030.008713%Not Available
Rectal haemorrhage07.12.03.001; 24.07.02.018--
Renal failure20.01.03.0050.063894%Not Available
Renal pain20.02.03.003--Not Available
Renal tubular necrosis20.01.07.003--Not Available
Respiratory disorder22.02.07.002--Not Available
Respiratory distress22.02.01.0120.029043%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.148117%
Respiratory tract irritation22.02.07.0120.008713%Not Available
Restlessness19.11.02.002; 17.02.05.0210.026138%
Retinal haemorrhage24.07.05.003; 06.10.01.0010.011617%Not Available
Retinitis11.01.06.011; 06.04.06.008--Not Available
Rhabdomyolysis15.05.05.0020.066798%
Rhinitis22.07.03.006; 11.01.13.004--
Scintillating scotoma17.17.02.007; 06.02.06.0050.014521%Not Available
Scleritis10.02.01.025; 06.04.07.002--Not Available
Screaming19.04.02.020; 08.01.03.0990.005809%Not Available
Scrotal oedema21.12.02.001--Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Shock24.06.02.0020.011617%Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin cancer23.08.02.002; 16.03.02.0020.040660%Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.0070.027300%Not Available
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