Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vismodegib
Drug ID BADD_D02365
Description Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.
Indications and Usage Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.
Marketing Status Prescription
ATC Code L01XJ01
DrugBank ID DB08828
KEGG ID D09992
MeSH ID C538724
PubChem ID 24776445
TTD Drug ID D03EDQ
NDC Product Code 50242-140
Synonyms HhAntag691 | NSC 747691 | NSC747691 | NSC-747691 | R 3616 | R3616 cpd | R-3616 | vismodegib | erivedge | GDC 0449 | GDC0449 | GDC-0449 | RG 3616 | RG3616 | RG-3616
Chemical Information
Molecular Formula C19H14Cl2N2O3S
CAS Registry Number 879085-55-9
SMILES CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Constipation07.02.02.0010.009591%
Cough22.02.03.001--
Cyst16.02.02.002; 08.03.05.0010.000799%Not Available
Cystitis20.03.02.002; 11.01.14.0010.000533%
Deafness04.02.01.0010.001598%Not Available
Death08.04.01.0010.012371%
Dehydration14.05.05.0010.005861%
Dementia19.20.02.001; 17.03.01.0010.002131%Not Available
Dementia Alzheimer's type17.03.06.001; 19.20.03.0010.000208%Not Available
Depression19.15.01.001--
Dermatitis23.03.04.0020.000533%Not Available
Diarrhoea07.02.01.0010.020780%
Diplopia17.17.01.005; 06.02.06.0020.000533%Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Distractibility19.21.02.0070.000533%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drug hypersensitivity10.01.01.001--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Duodenal ulcer07.04.02.0020.000799%
Dysarthria19.19.03.001; 17.02.08.001--
Dysgeusia17.02.07.003; 07.14.03.0010.057545%
Dyskinesia17.01.02.006--
Dyspepsia07.01.02.0010.002398%
Dysphagia07.01.06.0030.007726%
Dyspnoea22.02.01.004; 02.01.03.002--
Ear infection11.01.05.001; 04.03.01.0060.000533%Not Available
Electrolyte imbalance14.05.01.0020.001066%Not Available
Eosinophilia01.02.04.0010.000799%
Epiphyses premature fusion15.02.02.001; 05.05.03.0020.000799%Not Available
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