Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valdecoxib
Drug ID BADD_D02325
Description Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Indications and Usage For the treatment of osteoarthritis and dysmenorrhoea
Marketing Status Discontinued
ATC Code M01AH03
DrugBank ID DB00580
KEGG ID D02709
MeSH ID C406224
PubChem ID 119607
TTD Drug ID D0L6DA
NDC Product Code Not Available
Synonyms valdecoxib | Bextra | SC 65872 | SC-65872
Chemical Information
Molecular Formula C16H14N2O3S
CAS Registry Number 181695-72-7
SMILES CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emphysema22.01.02.002--Not Available
Enterocolitis haemorrhagic24.07.02.006; 07.08.01.007--Not Available
Eosinophilia01.02.04.001--
Epistaxis24.07.01.005; 22.04.03.001--
Eructation07.01.02.003--
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Fracture15.08.02.001; 12.04.02.001--
Frequent bowel movements07.02.04.002--Not Available
Fungal infection11.03.05.001--Not Available
Fungal skin infection23.09.02.001; 11.03.05.002--Not Available
Gastric cancer16.13.03.001; 07.21.02.001--Not Available
Gastric ulcer07.04.03.002--
Gastritis07.08.02.001--
Gastrooesophageal reflux disease07.02.02.003--
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal haemorrhage07.12.02.001; 24.07.02.009--Not Available
Gastrointestinal pain07.01.05.005--
Generalised oedema14.05.06.007; 08.01.07.004--
Genital candidiasis21.10.03.001; 11.03.03.002--Not Available
Glycosuria20.02.01.005--
Goitre05.02.01.001; 14.11.01.008--Not Available
Gout15.01.06.001; 14.09.01.001--Not Available
Haemangioma24.03.06.004; 16.02.01.002--Not Available
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