Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tolterodine
Drug ID BADD_D02244
Description Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Indications and Usage For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).
Marketing Status Prescription; Discontinued
ATC Code G04BD07
DrugBank ID DB01036
KEGG ID D00646
MeSH ID D000068737
PubChem ID 443879
TTD Drug ID D0BZ7W
NDC Product Code 65427-022; 0904-6593; 60687-330; 13668-190; 13668-189; 0904-6592; 60687-319
Synonyms Tolterodine Tartrate | Tartrate, Tolterodine | Tolterodine | Detrol | Detrol LA | Urotrol | PHA-686464B | PHA 686464B | PHA686464B | Detrusitol | Unidet
Chemical Information
Molecular Formula C22H31NO
CAS Registry Number 124937-51-5
SMILES CC1=CC(=C(C=C1)O)C(CCN(C(C)C)C(C)C)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry eye06.08.02.0010.001028%
Dry mouth07.06.01.0020.006680%
Dry skin23.03.03.001--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.0030.001541%
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.001028%Not Available
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.0250.002055%
Fungal infection11.03.05.0010.001028%Not Available
Gastrooesophageal reflux disease07.02.02.003--
Gastrointestinal pain07.01.05.005--
Hallucination19.10.02.002--
Headache17.14.01.0010.004110%
Hip fracture15.08.03.001; 12.04.01.0010.001028%
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.001541%
Hypertonic bladder20.03.03.003; 17.10.01.0030.001541%Not Available
Infection11.01.08.002--Not Available
Influenza like illness08.01.03.010--
Joint swelling15.01.02.0040.001028%Not Available
Kidney infection20.01.09.004; 11.01.14.0060.001028%
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.0050.000402%Not Available
Malaise08.01.01.0030.002055%
Memory impairment19.20.01.003; 17.03.02.0030.001541%
Micturition urgency20.02.02.0060.001541%
Milia23.02.03.0110.001028%Not Available
Multiple sclerosis17.16.01.001; 10.04.10.0080.001028%Not Available
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