Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol
Drug ID BADD_D02219
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Marketing Status Prescription; Discontinued
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00378
MeSH ID D013999
PubChem ID 33624
TTD Drug ID D05UVD
NDC Product Code 17478-365; 76478-002; 17478-366; 76478-001; 17478-189
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C13H24N4O3S
CAS Registry Number 26839-75-8
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysuria20.02.02.002--
Ear infection11.01.05.001; 04.03.01.006--Not Available
Erythema23.03.06.0010.000658%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.003--Not Available
Eye discharge06.04.05.0010.000439%Not Available
Eye disorder06.08.03.001--Not Available
Eye inflammation06.04.05.0020.000439%Not Available
Eye irritation06.04.05.0030.007243%Not Available
Eye pain06.08.03.0020.003292%
Eye swelling06.08.03.0030.001317%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.001097%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Fibrosis08.03.01.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Glaucoma06.03.01.0020.000658%
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.000439%Not Available
Hepatomegaly09.01.05.001--Not Available
Hyperaemia24.03.02.002--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.0020.000439%
Hyperhidrosis23.02.03.004; 08.01.03.0280.000439%
Hyperkalaemia14.05.03.0010.000658%
Hypersensitivity10.01.03.0030.000658%
Hypertension24.08.02.001--
Hypoaesthesia eye17.02.06.019; 06.01.01.007--Not Available
Hypoglycaemia14.06.03.001; 05.06.03.0010.000658%
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