Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tigecycline
Drug ID BADD_D02217
Description Tigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S. Food and Drug Administration (FDA) on June 17, 2005.
Indications and Usage Since glycylcyclines are similar to tetracyclines, they share many of the same side effects and contraindications as tetracyclines. These side effects may include nausea/vomiting, headache, photosensitivity, discoloration of growing teeth, and fetal damage.
Marketing Status Prescription
ATC Code J01AA12
DrugBank ID DB00560
KEGG ID D01079
MeSH ID D000078304
PubChem ID 54686904
TTD Drug ID D0G4OD
NDC Product Code 70121-1647; 0781-3481; 44657-0055; 60715-1001; 70594-035; 0008-4994; 58623-0048; 16729-364; 0008-4990; 70600-002; 63323-960; 68225-013; 60505-6098; 55150-228; 67680-002; 63415-0134; 71288-019
Synonyms Tigecycline | TBG-MINO | 9-(tert-Butylglycylamido)minocycline | Tygacil | GAR 936 | GAR-936 | GAR936
Chemical Information
Molecular Formula C29H39N5O8
CAS Registry Number 220620-09-7
SMILES CC(C)(C)NCC(=O)NC1=CC(=C2CC3CC4C(C(=O)C(=C(C4(C(=O)C3=C(C2=C1O)O)O)O)C(=O)N)N(C) C)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abnormal faeces07.01.03.001--Not Available
Abscess11.01.08.001--Not Available
Acidosis14.01.03.002--
Activated partial thromboplastin time13.01.02.033--Not Available
Activated partial thromboplastin time prolonged13.01.02.001--
Acute hepatic failure09.01.03.0010.000083%Not Available
Alanine aminotransferase increased13.03.01.0030.000639%
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Aspartate aminotransferase increased13.03.01.0060.000639%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block first degree02.03.01.004--
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Benign intracranial hypertension17.07.02.001--Not Available
Blood alkaline phosphatase13.04.02.010--Not Available
Blood bilirubin increased13.03.01.0080.001065%
Blood creatine phosphokinase increased13.04.01.001--
Blood creatinine increased13.13.01.0040.000319%
Blood fibrinogen decreased13.01.02.0030.000426%
Blood lactate dehydrogenase increased13.04.02.002--
Blood urea increased13.13.01.0060.000213%Not Available
Body temperature increased13.15.01.0010.000213%Not Available
Bradycardia02.03.02.0020.000319%Not Available
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