Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ticagrelor
Drug ID BADD_D02214
Description Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y12 receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage For the prevention of thrombotic events (for example stroke or heart attack) in patients with acute coronary syndrome or myocardial infarction with ST elevation.
Marketing Status Prescription
ATC Code B01AC24
DrugBank ID DB08816
KEGG ID D09017
MeSH ID D000077486
PubChem ID 9871419
TTD Drug ID D0WF7L
NDC Product Code 62147-0280; 69238-1134; 50923-0314; 15894-0030; 17228-7777; 58623-0131; 69037-0007; 45941-3055; 50379-0023; 55154-9618; 55111-969; 46708-883; 49587-109; 17228-0777; 50379-0011; 0186-0777; 17228-0776; 49187-0205; 76072-1016; 0186-0776; 65372-1198
Synonyms Ticagrelor | Brilique | AZD 6140 | AZD6140 | AZD-6140 | Brilinta | 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Chemical Information
Molecular Formula C23H28F2N6O4S
CAS Registry Number 274693-27-5
SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.0020.286980%
Dyspnoea at rest02.01.03.007; 22.02.01.025--Not Available
Dyspnoea exertional22.02.01.005; 02.01.03.0030.004405%Not Available
Dyspnoea paroxysmal nocturnal22.02.01.018; 02.01.03.004--Not Available
Dysuria20.02.02.002--
Ear disorder04.03.01.001--Not Available
Ear haemorrhage24.07.01.004; 04.03.01.0020.001259%Not Available
Ear pain04.03.01.0030.001259%
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.001888%Not Available
Electrocardiogram abnormal13.14.05.0010.010069%Not Available
Electrocardiogram QT prolonged13.14.05.004--
Electrocardiogram ST segment elevation13.14.05.0250.006293%Not Available
Embolic stroke24.01.04.010; 17.08.01.0320.001259%Not Available
Emotional disorder19.04.02.005--Not Available
Epistaxis24.07.01.005; 22.04.03.0010.018880%
Erythema23.03.06.001--Not Available
Extrasystoles02.03.02.0030.001259%Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.003147%Not Available
Facial paralysis17.04.03.0080.001259%Not Available
Faeces discoloured07.01.03.0020.005664%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling cold08.01.09.0080.001888%Not Available
Feeling hot08.01.09.009--Not Available
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