Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiagabine
Drug ID BADD_D02210
Description Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor.
Indications and Usage For the treatment of partial seizures
Marketing Status Prescription; Discontinued
ATC Code N03AG06
DrugBank ID DB00906
KEGG ID D08588
MeSH ID D000078308
PubChem ID 60648
TTD Drug ID D0ED7U
NDC Product Code 69238-1105; 69238-1106; 69238-1104; 69238-1107
Synonyms Tiagabine | N-(4,4-di(3-Methylthien-2-yl)but-3-enyl)nipecotic acid | Gabitril | NO 329 | NO-329 | Tiagabine Hydrochloride | (R)-(4,4-bis(3-Methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid, Hydrochloride | Tiagabine, (S)-isomer | NO 328 | NO-328
Chemical Information
Molecular Formula C20H25NO2S2
CAS Registry Number 115103-54-3
SMILES CC1=C(SC=C1)C(=CCCN2CCCC(C2)C(=O)O)C3=C(C=CS3)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Gingival hyperplasia07.09.03.002--Not Available
Gingivitis11.01.04.013; 07.09.03.003--
Glossitis07.14.01.001--Not Available
Goitre14.11.01.008; 05.02.01.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hemiplegia17.01.04.002--Not Available
Hepatomegaly09.01.05.001--Not Available
Hernia08.01.04.001--Not Available
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Herpes zoster23.09.03.002; 11.05.02.003--
Hiccups22.02.04.002; 07.01.06.009--
Hirsutism23.02.04.001; 05.05.01.005--
Hostility19.05.01.003--Not Available
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hypercholesterolaemia14.08.01.001--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperkinesia17.01.02.008--Not Available
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hyperventilation22.02.01.006; 19.01.02.004--Not Available
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