Pharmaceutical Information |
Drug Name |
Thyrotropin releasing hormone |
Drug ID |
BADD_D02209 |
Description |
Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary.
Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary hypothyroidism and acromegaly. |
Indications and Usage |
|
Marketing Status |
Discontinued |
ATC Code |
V04CJ02 |
DrugBank ID |
DB09421
|
KEGG ID |
D00176
|
MeSH ID |
D013973
|
PubChem ID |
131841495
|
TTD Drug ID |
D08BTB
|
NDC Product Code |
72969-111 |
Synonyms |
Thyrotropin-Releasing Hormone | Thyrotropin Releasing Hormone | Thyrotropin-Releasing Factor | Thyrotropin Releasing Factor | Protirelin | Antepan | Protirelin Tartrate (1:1) | Proterelin Tartrate | Thyrotropin-Releasing Hormone Tartrate | Thyrotropin Releasing Hormone Tartrate | Relefact TRH | TRH, Relefact | Thypinone | Thyroliberin | Thyroliberin TRH Merck | TRH Prem | Prem, TRH | Proterelin Tartrate Hydrate | Hydrate, Proterelin Tartrate | Tartrate Hydrate, Proterelin | Abbott-38579 | Abbott 38579 | Abbott38579 | Stimu-TSH | Stimu TSH | StimuTSH | TRH Ferring |
|
Chemical Information |
Molecular Formula |
C16H22N6O4 |
CAS Registry Number |
24305-27-9 |
SMILES |
C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N |
Chemical Structure |
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ADR Related Proteins Induced by Drug |
ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
Not Available | Not Available | Not Available | Not Available | Not Available |
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ADRs Induced by Drug |
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