Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thiothixene
Drug ID BADD_D02204
Description A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics.
Indications and Usage For the management of schizophrenia.
Marketing Status Prescription; Discontinued
ATC Code N05AF04
DrugBank ID DB01623
KEGG ID D00374
MeSH ID D013888
PubChem ID 5454
TTD Drug ID D0E0LQ
NDC Product Code 60219-1675; 58159-042; 60219-1676; 53808-1129; 70518-1703; 51407-278; 70518-2544; 51079-589; 60219-1673; 0378-5010; 51407-276; 70954-015; 70518-3147; 60219-1674; 70518-2340; 70518-2594; 51407-277; 0378-2002; 0378-1001; 0378-3005; 70954-014; 51407-275; 70954-017; 48954-575; 70954-016; 51079-588
Synonyms Thiothixene | Tiotixene | Navane
Chemical Information
Molecular Formula C23H29N3O2S2
CAS Registry Number 5591-45-7
SMILES CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ParkinsonismNADH-ubiquinone oxidoreductase chain 1P03886Not Available8098932; 9309697
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperprolactinaemia05.03.01.002--Not Available
Hyperpyrexia08.05.02.002--Not Available
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice09.01.01.004; 23.03.03.030; 01.06.04.004--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Loss of consciousness17.02.04.004--Not Available
Mastication disorder15.03.01.009; 07.01.06.016; 17.05.03.006--Not Available
Menstruation irregular21.01.01.005; 05.05.01.008--
Miosis17.02.11.002; 06.05.03.003--Not Available
Muscle spasms15.05.03.004--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nasal congestion22.04.04.001--
Nausea07.01.07.001--
Neuroleptic malignant syndrome17.05.02.003; 15.05.04.015; 12.03.01.003; 08.05.01.005--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Pancytopenia01.03.03.003--Not Available
Parkinsonism17.01.05.003--Not Available
Photosensitivity reaction23.03.09.003--
Polydipsia14.05.02.001; 05.03.03.002--Not Available
Pregnancy test false positive13.10.05.003--Not Available
Protrusion tongue07.14.02.002; 17.02.05.037--Not Available
Pruritus23.03.12.001--
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