Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status Prescription
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 0054-0469; 60505-3882; 51224-426; 43598-394; 27241-177; 42291-806; 51224-425; 65977-0085; 47335-277; 31722-822; 68180-408; 70436-102; 51407-481; 42291-807; 65085-0064; 65015-831; 0054-0468; 69452-117; 69766-076; 43598-395; 42973-179; 62756-871; 31722-821; 64330-066; 68180-409; 64567-0025; 68682-421; 63827-1013; 51407-480; 69452-118; 47335-179; 68682-422; 60505-3883; 70436-101; 27241-176
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dystonia17.01.03.0010.015686%Not Available
Dysuria20.02.02.002--
Eating disorder14.03.01.008; 19.09.01.0080.003921%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Electrocardiogram abnormal13.14.05.0010.002614%Not Available
Electrocardiogram QT prolonged13.14.05.004--
Emotional disorder19.04.02.0050.003921%Not Available
Epilepsy17.12.03.0020.002614%Not Available
Extrapyramidal disorder17.01.02.007--
Extrasystoles02.03.02.003--Not Available
Eye disorder06.08.03.001--Not Available
Facial bones fracture15.08.04.001; 12.04.05.0020.002614%Not Available
Fall12.01.08.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flat affect19.04.01.0040.002614%Not Available
Fracture12.04.02.001; 15.08.02.0010.002614%
Gait disturbance17.02.05.016; 08.01.02.0020.013072%
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Generalised tonic-clonic seizure17.12.01.0020.002614%Not Available
Glossodynia07.14.02.0010.002614%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.002614%Not Available
Hallucination19.10.02.0020.006536%
Hallucination, auditory19.10.02.0030.003921%Not Available
Headache17.14.01.001--
Heart rate decreased13.14.04.0010.002614%Not Available
Heart rate increased13.14.04.002--Not Available
Hip fracture15.08.03.001; 12.04.01.0010.003921%
Hunger14.03.02.012; 08.01.09.0030.002614%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.010457%
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