Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status approved; investigational
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 51224-425; 67386-421; 68180-409; 63827-1013; 65977-0085; 47335-277; 51407-481; 27241-177; 60505-3882; 65085-0064; 27241-176; 47335-179; 69452-117; 70436-102; 43598-395; 60505-3883; 70436-101; 57821-010; 51407-480; 68682-422; 31722-821; 43598-394; 51224-426; 69452-118; 69766-076; 31722-822; 67386-422; 42973-179; 68180-408; 68682-421; 64330-066; 64567-0025; 65015-831
UNII Z9O08YRN8O
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Extrasystoles02.03.02.003--Not Available
Eye disorder06.08.03.001--Not Available
Fall12.01.08.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flat affect19.04.01.0040.000538%Not Available
Gait disturbance17.02.05.016; 08.01.02.002; 15.03.05.0130.007375%
Generalised tonic-clonic seizure17.12.01.0020.000538%Not Available
Glossodynia07.14.02.0010.000538%Not Available
Haematemesis24.07.02.011; 07.12.02.0020.000538%Not Available
Hallucination19.10.04.0030.003284%
Hallucination, auditory19.10.04.0040.001454%Not Available
Headache17.14.01.001--
Hepatocellular injury09.01.07.0080.000538%Not Available
Hunger14.03.02.012; 08.01.09.0030.001184%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.006299%
Hypertonia17.05.02.001; 15.05.04.0070.001454%Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Hypotonia17.05.02.002; 15.05.04.0080.000808%Not Available
Influenza like illness08.01.03.0100.001830%
Insomnia19.02.01.002; 17.15.03.0020.015774%
Intentional self-injury19.12.01.002; 12.01.08.0360.001454%Not Available
Irritability19.04.02.013; 08.01.03.0110.004845%
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.0040.004468%
Leukopenia01.02.02.001--Not Available
Mastication disorder15.03.05.022; 17.05.03.006; 07.01.06.0160.002746%Not Available
Memory impairment19.20.01.003; 17.03.02.0030.001992%
Menstruation irregular21.01.01.005; 05.05.01.008--
Mental impairment19.21.02.003; 17.03.03.0020.001830%Not Available
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