Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Teriflunomide
Drug ID BADD_D02165
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Indications and Usage Used in the treatment of relapsing forms of multiple sclerosis (MS).
Marketing Status Prescription
ATC Code L04AA31
DrugBank ID DB08880
KEGG ID D10172
MeSH ID C527525
PubChem ID 54684141
TTD Drug ID Not Available
NDC Product Code 69238-1303; 65727-058; 12579-186; 69238-1304; 66499-0059; 59285-001; 69539-032; 47621-049; 17337-0070; 69037-0016; 58468-0211; 63850-8081; 12579-185; 46708-888; 12579-191; 53747-061; 69539-033; 14501-0086; 58468-0210; 59651-036; 66039-916; 0115-1565; 12579-190
Synonyms teriflunomide | (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | (2Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide | RS 61980 | Aubagio | HMR1726 | HMR-1726 | A 771726 | A 1726 | A771726 | A-771726 | A77 1726
Chemical Information
Molecular Formula C12H9F3N2O2
CAS Registry Number 163451-81-8
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.0060.001158%Not Available
Cough22.02.03.001--
Crohn's disease10.02.01.005; 07.08.01.0150.004053%Not Available
Crying08.01.03.005; 19.04.02.002; 17.02.05.013; 12.02.11.001--Not Available
Cyst16.02.02.002; 08.03.05.0010.001737%Not Available
Cystitis20.03.02.002; 11.01.14.0010.003474%
Deafness04.02.01.001--Not Available
Death08.04.01.001--
Decreased activity19.11.01.002; 08.01.01.0060.001158%Not Available
Decreased interest19.15.02.0040.001158%Not Available
Decubitus ulcer23.03.11.0060.001158%Not Available
Defaecation urgency07.02.04.0010.001737%Not Available
Dehydration14.05.05.001--
Delirium19.13.02.001--
Delusion19.10.01.001--
Dental caries07.09.01.0010.002316%
Depressed mood19.15.02.0010.006369%Not Available
Depression19.15.01.0010.030108%
Dermal cyst23.10.02.001; 16.26.02.0010.001158%Not Available
Dermatitis23.03.04.0020.002895%Not Available
Dermatitis bullous23.03.01.0020.002316%
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.0030.001158%Not Available
Diabetes mellitus14.06.01.001; 05.06.01.001--Not Available
Diarrhoea07.02.01.0010.250703%
Diarrhoea haemorrhagic24.07.02.004; 07.02.01.0020.004053%Not Available
Diplopia06.02.06.002; 17.17.01.005--Not Available
Discomfort08.01.08.0030.004053%Not Available
Disorientation17.02.05.015; 19.13.01.002--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
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