Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir disoproxil fumarate
Drug ID BADD_D02156
Description Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Indications and Usage Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
Marketing Status Prescription
ATC Code J05AF07
DrugBank ID DB00300
KEGG ID D01982
MeSH ID D000068698
PubChem ID 5486830
TTD Drug ID D0R3FP
NDC Product Code 65862-397; 66406-0103; 63285-735; 68668-351; 53104-7654; 68554-0031; 65862-421; 16714-820; 14799-2022; 60505-4666; 69076-105; 33342-501; 70518-1002; 69097-533; 65015-833; 61958-0404; 53808-1128; 61958-0403; 61958-0406; 50268-758; 61958-0401; 47234-0401; 64380-714; 63285-736; 63285-737; 67835-0020; 50683-0289; 65015-667; 70518-2151; 42291-800; 65862-819; 65862-818; 65862-820; 14593-946; 61958-0405; 70966-0023; 52562-020; 42385-741; 59997-0002; 31722-535; 42931-101; 65015-835; 76302-004; 63285-872
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C23H34N5O14P
CAS Registry Number 202138-50-9
SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.004--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypokalaemia14.05.03.002--
Hypophosphataemia14.04.03.001--
Insomnia19.02.01.002; 17.15.03.002--
Lactic acidosis14.01.01.002--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Myopathy15.05.05.001--Not Available
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutrophil count decreased13.01.06.010--
Osteomalacia20.01.01.002; 15.02.03.001; 14.04.04.001--Not Available
Pain08.01.08.004--
Pancreatitis07.18.01.001--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Polyuria20.02.03.002--Not Available
Proteinuria20.02.01.011--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Renal tubular disorder20.05.03.004--Not Available
Renal tubular necrosis20.01.07.003--Not Available
Rhabdomyolysis15.05.05.002--
Sinusitis22.07.03.007; 11.01.13.005--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
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