Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir disoproxil
Drug ID BADD_D02155
Description Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Indications and Usage Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
Marketing Status Prescription
ATC Code J05AF07
DrugBank ID DB00300
KEGG ID D01982
MeSH ID D000068698
PubChem ID 5481350
TTD Drug ID D0D9HW
NDC Product Code 68554-0046
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C19H30N5O10P
CAS Registry Number 201341-05-1
SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood albumin decreased13.09.01.0010.013329%Not Available
Blood bilirubin increased13.03.01.0080.048872%
Blood bilirubin unconjugated increased13.03.01.0240.013329%Not Available
Blood creatine phosphokinase increased13.04.01.0010.062201%
Blood creatine phosphokinase MB increased13.04.01.0060.017772%Not Available
Blood creatinine increased13.13.01.0040.133288%
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.008886%
Blood lactic acid increased13.02.01.0150.013329%Not Available
Blood triglycerides increased13.12.03.001--Not Available
Blood urea increased13.13.01.0060.013329%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.017772%Not Available
Bone pain15.02.01.0010.053315%
Breast cancer16.10.01.001; 21.05.01.003--Not Available
Breast enlargement21.05.04.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cardiac arrest02.03.04.001--
Cardiomegaly02.04.02.0010.002318%Not Available
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.001--Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.003--Not Available
Chills08.01.09.001; 15.05.03.016--
Cholestasis09.01.01.0010.013329%Not Available
Chromaturia20.02.01.0020.013329%
Chronic hepatitis B11.05.06.005; 09.01.09.0080.039986%Not Available
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Clavicle fracture15.08.03.010; 12.04.01.0100.008886%Not Available
Cleft lip and palate07.05.08.003; 03.04.02.0030.008886%Not Available
Confusional state17.02.03.005; 19.13.01.001--
Constipation07.02.02.001--
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