Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tamoxifen citrate
Drug ID BADD_D02112
Description Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers as patients generally have better survival, side effect profiles, and compliance with [anastrozole].[A1026] Tamoxifen was granted FDA approval on 30 December 1977.[L7799]
Indications and Usage Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
Marketing Status Prescription; Discontinued
ATC Code L02BA01
DrugBank ID DB00675
KEGG ID D00966
MeSH ID D013629
PubChem ID 2733525
TTD Drug ID D07KSG
NDC Product Code 89141-123; 65319-1051; 63275-9865; 63187-976; 51407-440; 60429-910; 63739-269; 68071-5005; 59651-300; 50090-0942; 70771-1185; 71335-1424; 0591-2472; 68382-827; 0378-0144; 63739-143; 65319-1151; 46014-1180; 59651-299; 13632-654; 51927-5076; 0378-0274; 71335-0893; 51927-2976; 51407-439; 17337-0035; 51552-0838; 60429-909; 51862-642; 46014-1200; 51862-447; 51862-446; 0591-2473; 51862-682; 68382-826; 17337-0034; 51862-643; 50090-0485; 71335-0237; 46014-1190; 49452-7571; 70518-2721; 36974-0048; 46014-1015; 70771-1184
Synonyms Tamoxifen | ICI-47699 | ICI 47699 | ICI47699 | Nolvadex | Novaldex | Tamoxifen Citrate | Citrate, Tamoxifen | Tomaxithen | Zitazonium | ICI-46474 | ICI 46474 | ICI46474 | ICI-46,474 | ICI 46,474 | ICI46,474 | Soltamox
Chemical Information
Molecular Formula C32H37NO8
CAS Registry Number 54965-24-1
SMILES CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O) O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Walking disability26.01.01.009--Not Available
Haemorrhage24.07.01.002--Not Available
Cutaneous lupus erythematosus23.03.02.008; 15.06.02.007; 10.04.03.007--Not Available
Vulvovaginal pruritus23.03.12.009; 21.08.02.004--Not Available
Precocious puberty21.03.02.009; 05.05.03.001--
Urine output13.13.03.003--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Ischaemic cerebral infarction24.04.06.013; 17.08.01.022--Not Available
Benign neoplasm16.02.02.007--Not Available
Breast cancer male21.05.01.008; 16.10.01.002--Not Available
Ocular toxicity12.03.01.031; 06.11.01.006--Not Available
Embolism24.01.01.009--
Inflammation08.01.05.007--Not Available
Metastatic neoplasm16.16.01.007--Not Available
Optic nerve disorder17.04.05.004; 06.02.08.001--
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Polyp16.02.02.005; 08.01.06.010--Not Available
Disease progression08.01.03.038--
Hyperlipidaemia14.08.03.001--
Bone marrow failure01.03.03.005--
Liver injury12.01.02.003; 09.01.07.022--Not Available
Oestrogenic effect05.05.04.004--Not Available
Accidental exposure to product12.06.02.002--Not Available
Liver function test increased13.03.01.044--Not Available
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