Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tacrine hydrochloride
Drug ID BADD_D02104
Description A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market.
Indications and Usage For the palliative treatment of mild to moderate dementia of the Alzheimer's type.
Marketing Status Discontinued
ATC Code N06DA01
DrugBank ID DB00382
KEGG ID D02068
MeSH ID D013619
PubChem ID 2723754
TTD Drug ID D0E6YQ
NDC Product Code Not Available
Synonyms Tacrine | 9-Amino-1,2,3,4-Tetrahydroacridine | 1,2,3,4-Tetrahydro-9-acridinamine | Tetrahydroaminoacridine | 1,2,3,4-Tetrahydroaminoacridine | Romotal | Tenakrin | THA | Cognex | Tacrine Hydrochloride
Chemical Information
Molecular Formula C13H15ClN2
CAS Registry Number 1684-40-8
SMILES C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AstheniaCholinesteraseP06276T99799Not Available
DementiaApolipoprotein EP02649T21689Not Available
DiarrhoeaCholinesteraseP06276T99799Not Available
DizzinessCholinesteraseP06276T99799Not Available
HepatotoxicityCytochrome P450 1A2P05177Not AvailableNot Available
VomitingCholinesteraseP06276T99799Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myocardial infarction02.02.02.007; 24.04.04.009--
Myopathy15.05.05.001--Not Available
Nausea07.01.07.001--
Nephrolithiasis20.04.01.002--
Nervousness19.06.02.003--Not Available
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurosis19.06.01.001--Not Available
Nocturia20.02.03.001--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oesophagitis07.08.05.001--
Osteoporosis14.04.04.002; 15.02.03.002--
Otitis media11.01.05.004; 04.05.01.001--
Ovarian cancer21.11.01.003; 16.12.04.001--Not Available
Palpitations02.01.02.003--
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Paranoia19.05.01.005--Not Available
Paresis17.01.04.008--Not Available
Peptic ulcer perforation07.04.07.003--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Phlebitis24.05.03.001; 12.02.01.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Polyuria20.02.03.002--Not Available
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Psoriasis23.03.14.002; 10.02.01.036--Not Available
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