Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Streptozocin
Drug ID BADD_D02073
Description An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Indications and Usage For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).
Marketing Status Prescription
ATC Code L01AD04
DrugBank ID DB00428
KEGG ID D05932
MeSH ID D013311
PubChem ID 29327
TTD Drug ID D0I8RR
NDC Product Code 0703-4636
Synonyms Streptozocin | Streptozotocine | 2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose | Streptozotocin | Zanosar
Chemical Information
Molecular Formula C8H15N3O7
CAS Registry Number 18883-66-4
SMILES CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Q9UHR4Not Available2332119; 7523453; 2551653; 2537893; 1661694; 1331176; 16358398; 2227134; 10391142; 10449437; 3548422; 2838251; 12882908; 2180315; 2820811; 10871198; 8127894; 1324860
Diabetes mellitusPolyunsaturated fatty acid lipoxygenase ALOX15P39654Not Available25598081
HyperglycaemiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
HyperglycaemiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
HyperinsulinismBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1Q9UHR4Not Available2332119; 7523453; 2551653; 2537893; 1661694; 1331176; 16358398; 2227134; 10391142; 10449437; 3548422; 2838251; 12882908; 2180315; 2820811; 10871198; 8127894; 1324860
HyperphagiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
HyperphagiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
NeurotoxicityAcetylcholinesteraseP21836Not Available25823512
NeurotoxicityCaspase-3P55213Not Available25823512
PolydipsiaMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
PolydipsiaEndoplasmic reticulum chaperone BiPP06761Not Available25725139
Vascular anomalies congenital NECMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
Vascular anomalies congenital NECEndoplasmic reticulum chaperone BiPP06761Not Available25725139
Weight decreasedEndoplasmic reticulum chaperone BiPP06761Not Available25725139
Weight decreasedMicrotubule-associated proteins 1A/1B light chain 3BQ62625Not Available25725139
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insulinoma16.24.02.003; 07.21.09.001; 05.08.01.004--Not Available
Ketonuria20.02.01.009--Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Necrosis24.04.02.006; 08.03.03.001--Not Available
Neoplasm malignant16.16.01.001--Not Available
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.002--Not Available
Nephropathy toxic20.05.03.002; 12.03.01.010--Not Available
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Platelet count decreased13.01.04.001--
Proteinuria20.02.01.011--
Renal tubular acidosis20.05.03.003; 14.01.01.005--Not Available
Road traffic accident12.01.08.006--Not Available
Shock hypoglycaemic14.06.03.003; 05.06.03.003--Not Available
Tenderness08.01.08.005--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
Fanconi syndrome acquired20.05.03.012; 14.01.01.013--Not Available
Protein urine present13.13.02.006--Not Available
Hepatic enzyme increased13.03.01.019--Not Available
Haematotoxicity12.03.01.025; 01.05.01.007--Not Available
Inflammation08.01.05.007--Not Available
Chronic kidney disease20.01.03.017--
Bone marrow failure01.03.03.005--
The 2th Page    First    Pre   2    Total 2 Pages