Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Spironolactone
Drug ID BADD_D02066
Description Spironolactone is a potassium sparing diuretic like [eplerenone] that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention.[A11837]. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered.[A11837,A178246] It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.[Label] Off label uses of spironolactone involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris.[A178135] Spironolactone is also frequently used in medical gender transition.[A178138] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243,L6187]
Indications and Usage Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.
Marketing Status Prescription; Discontinued
ATC Code C03DA01
DrugBank ID DB00421
KEGG ID D00443
MeSH ID D013148
PubChem ID 5833
TTD Drug ID D0EP0C
NDC Product Code 63629-1062; 70518-1746; 71335-0966; 68382-661; 59651-426; 63629-5341; 68071-4374; 71205-146; 63629-2437; 70518-2384; 68071-2606; 50090-3916; 70518-1742; 65162-511; 63187-841; 51079-980; 50090-1292; 0025-1031; 71335-0053; 63629-1095; 55525-0002; 70518-0563; 71335-0304; 55700-934; 38779-0096; 63629-1065; 67296-1692; 67296-1403; 63629-2436; 59746-218; 49452-7220; 70518-2588; 0378-0243; 63187-861; 53489-329; 70518-0455; 67544-310; 59746-216; 0378-2146; 55700-713; 51079-103; 59651-427; 51655-344; 70518-2385; 71335-1546; 16714-084; 76420-062; 63629-2438; 63629-1061; 69584-852; 63629-8539; 43063-832; 16729-227; 70518-1314; 70518-3118; 16729-226; 0904-6927; 70771-1027; 70934-367; 68788-7019; 63629-4094; 53002-1707; 71205-147; 82298-121; 63629-1066; 68382-662; 68788-7297; 42708-126; 63629-1094; 51079-979; 53002-4720; 68788-7051; 71610-287; 55154-1495; 70771-1029; 55700-953; 69584-854; 63187-634; 16637-0020; 0378-0437; 0615-8178; 53746-514; 53746-515; 63629-1064; 60687-487; 70518-1334; 43063-974; 63629-1092; 0615-8221; 16714-086; 51552-0276; 63629-1093; 65162-515; 0025-1001; 59746-217; 70518-2589; 63739-545; 71335-1604; 63739-544; 70518-2386; 70518-0603; 70771-1028; 43063-835; 76420-063; 67296-1100; 0025-1041; 69584-853; 79572-032; 70966-0028; 42708-101; 16714-085; 50090-3580; 54348-340; 53489-143; 71335-0401; 68382-660; 71610-288; 16729-225; 50090-1308; 60687-476; 70518-2461; 71205-148; 57582-030; 61907-031; 65162-514; 55154-5517; 72189-329; 63629-1067; 46438-0033; 53746-511; 50090-3747; 61919-772; 55154-3556; 59651-428; 71335-1586; 45541-1134; 51927-1377; 53489-328; 70518-2585; 60687-465; 63629-1830; 71610-102
Synonyms Spironolactone | Spirolactone | Veroshpiron | Verospirone | Spiractin | Spirobeta | Spirogamma | Spirolang | Spirono-Isis | Spirono Isis | Spironone | Spirospare | Aldactone | Verospiron | Aldactone A | Aquareduct | Duraspiron | Espironolactona Alter | Espironolactona Mundogen | Flumach | Frumikal | Jenaspiron | Novo-Spiroton | Novo Spiroton | NovoSpiroton | Practon | SC-9420 | SC 9420 | SC9420 | Spiro L.U.T. | Spiro Von Ct | Ct, Spiro Von | Von Ct, Spiro
Chemical Information
Molecular Formula C24H32O4S
CAS Registry Number 52-01-7
SMILES CC(=O)SC1CC2=CC(=O)CCC2(C3C1C4CCC5(C4(CC3)C)CCC(=O)O5)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.0330.000519%Not Available
Jaundice01.06.04.004; 09.01.01.004; 23.03.03.0300.000432%Not Available
Laboratory test abnormal13.18.01.001--Not Available
Lactic acidosis14.01.01.0020.000346%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.0020.000259%
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Loss of consciousness17.02.04.0040.000951%Not Available
Loss of libido19.08.03.0030.000173%Not Available
Lung disorder22.02.07.001--Not Available
Malaise08.01.01.003--
Melaena24.07.02.013; 07.12.02.0040.000605%Not Available
Meningioma16.30.01.005; 17.20.01.0050.000173%Not Available
Menstruation irregular21.01.01.005; 05.05.01.0080.000259%
Metabolic acidosis14.01.01.0030.000180%Not Available
Metabolic alkalosis14.01.02.0040.000173%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.0040.000346%Not Available
Muscle haemorrhage24.07.01.037; 15.05.03.0170.000173%Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.001297%
Myocardial infarction24.04.04.009; 02.02.02.007--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.0030.000173%Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
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