| Pharmaceutical Information |
| Drug Name |
Sodium oxybate |
| Drug ID |
BADD_D02047 |
| Description |
Sodium oxybate (Xyrem) is a central nervous system depressant used for the treatment of cataplexy and extreme daytime sleepiness (EDS) associated with narcolepsy. It is the sodium salt of gamma hydroxybutyric acid (GHB) which is an endogenous compound and a metabolite of the neurotransmitter GABA. The exact mechanism of action for treating EDS and cataplexy is not known but is is hypothesised that its therapeutic effects are due to GABA(B) effects on noradrenergic, dopaminaergic and thalamocorticol neurons. The drug follows non-linear pharmacokinetics. As it has been associated with misuse/abuse it is strictly controlled and all patients and prescribers must enroll in the sodium oxybate REMs program in order to gain access to the medication. |
| Indications and Usage |
For the treatment of cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy. |
| Marketing Status |
approved |
| ATC Code |
N01AX11; N07XX04 |
| DrugBank ID |
DB09072
|
| KEGG ID |
D05866
|
| MeSH ID |
D012978
|
| PubChem ID |
23663870
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
13551-001; 49812-0207; 0054-9628; 69238-2391; 0792-4356; 13551-002; 13551-003; 68727-100; 61960-0221; 13551-004; 59116-5950 |
| UNII |
7G33012534
|
| Synonyms |
Sodium Oxybate | Oxybate, Sodium | Sodium Oxybutyrate | Oxybutyrate, Sodium | Sodium gamma-Hydroxybutyrate | Sodium gamma Hydroxybutyrate | 4-Hydroxybutyrate Sodium | 4 Hydroxybutyrate Sodium | Oxybate Sodium | gamma-Hydroxybutyrate | gamma Hydroxybutyrate | Somsanit | Xyrem |
|
| Chemical Information |
| Molecular Formula |
C4H7NaO3 |
| CAS Registry Number |
502-85-2 |
| SMILES |
C(CC(=O)[O-])CO.[Na+] |
| Chemical Structure |
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| ADRs Induced by Drug |
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