Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage It may be used for premature ejaculation and vascular headaches as off-label indications.
Marketing Status Prescription; Discontinued
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 0904-6925; 68180-352; 63187-478; 70518-2512; 0904-6924; 70518-1461; 70518-1040; 70518-0153; 0904-6926; 50090-3562; 43353-817; 68180-353; 50090-5848; 43353-809; 0615-7990; 67296-1199; 63187-055; 0615-7989; 71335-0404; 68645-589; 70518-0378; 50090-0989; 0615-7991; 68180-351; 68788-7329; 63187-212; 68071-4400; 76282-212; 76282-213; 70518-1617; 65427-009; 76282-214
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.0020.001270%
Dry skin23.03.03.001--
Dry throat22.02.05.004; 07.06.01.0050.000060%Not Available
Duodenal ulcer perforation07.04.02.0030.000272%Not Available
Duodenitis07.08.03.0010.000060%Not Available
Dysaesthesia17.02.06.0030.000181%
Dysarthria19.19.03.001; 17.02.08.0010.001088%
Dysgeusia17.02.07.003; 07.14.03.0010.000786%
Dyskinesia17.01.02.0060.001723%
Dyslexia19.21.01.003; 17.02.03.0090.000060%Not Available
Dysmenorrhoea21.01.01.0020.000121%
Dyspepsia07.01.02.0010.000786%
Dysphagia07.01.06.003--
Dysphonia22.02.05.005; 19.19.03.002; 17.02.08.004--
Dysphoria19.04.02.004--Not Available
Dyspnoea22.02.01.004; 02.01.03.002--
Dystonia17.01.03.0010.000816%Not Available
Dysuria20.02.02.0020.000907%
Ear infection11.01.05.001; 04.03.01.006--Not Available
Ear malformation04.06.02.001; 03.13.02.0010.000091%Not Available
Ear pain04.03.01.003--
Ear swelling04.03.01.0140.000151%Not Available
Eating disorder19.09.01.008; 14.03.01.008--Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.0010.000181%Not Available
Ectopic pregnancy18.02.02.0020.000121%Not Available
Eczema23.03.04.006--
Ejaculation delayed21.03.01.0010.000121%Not Available
Ejaculation disorder21.03.01.0020.000060%
Ejaculation failure21.03.01.003--Not Available
Electrocardiogram QRS complex prolonged13.14.05.0030.000212%Not Available
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