Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Salmeterol
Drug ID BADD_D01981
Description Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol].[A190459] Salmeterol was first described in the literature in 1988.[A190477] Salmeterol's structure is similar to salbutamol's with an aralkyloxy-alkyl substitution on the amine.[A183737] Salmeterol was granted FDA approval on 4 February 1994.[L11542]
Indications and Usage For the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Marketing Status Prescription; Discontinued
ATC Code R03AC12
DrugBank ID DB00938
KEGG ID D05792
MeSH ID D000068299
PubChem ID 5152
TTD Drug ID D0L5YV
NDC Product Code 63850-3912
Synonyms Salmeterol Xinafoate | Xinafoate, Salmeterol | Salmeterol | Serevent
Chemical Information
Molecular Formula C25H37NO4
CAS Registry Number 89365-50-4
SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Surgical and medical proceduresBeta-2 adrenergic receptorP07550T5252211804270; 11586955; 10988267; 10984540; 11306963; 10340917; 9399966
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dry mouth07.06.01.002--
Dysmenorrhoea21.01.01.002--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.0020.044864%
Ear infection11.01.05.001; 04.03.01.006--Not Available
Ear pain04.03.01.003--
Eczema23.03.04.006--
Epistaxis24.07.01.005; 22.04.03.001--
Extrasystoles02.03.02.003--Not Available
Eye infection11.01.06.001; 06.04.05.007--
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.0040.014955%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Food allergy10.01.01.012--Not Available
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal infection11.01.07.012; 07.19.02.005--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.0010.029909%
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.0010.014955%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Injury12.01.08.004--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Keratitis06.04.02.002--
Laryngitis22.07.03.001; 11.01.13.001--
Laryngospasm22.04.02.002--
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