Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ropivacaine hydrochloride
Drug ID BADD_D01968
Description Ropivacaine is an aminoamide local anaesthetic drug commonly marketed by AstraZeneca under the trade name Naropin. It is present as a racemic mixture of the enantiomers containing equal proportions of the “S” and “R” forms. The marketed form contains the single S-enantiomer as the active ingredient.
Indications and Usage Used in obstetric anesthesia and regional anesthesia for surgery.
Marketing Status Prescription; Discontinued
ATC Code N01BB09
DrugBank ID DB00296
KEGG ID D04048
MeSH ID D000077212
PubChem ID 175804
TTD Drug ID D09RHQ
NDC Product Code 70069-063; 43066-015; 0409-9300; 65145-108; 43066-023; 55150-201; 63323-285; 55150-196; 63323-286; 55150-195; 46014-1058; 25021-671; 0409-9301; 65145-109; 63323-287; 55150-198; 70518-2681; 63323-288; 49386-025; 55150-199; 65145-107; 48954-722; 0143-9265; 67184-0022; 25021-652; 0143-9263; 70069-061; 55150-197; 76339-124; 0404-9924; 70069-064; 17478-081; 43066-019; 51552-1590; 70516-0165; 0143-9264; 0409-9302; 49452-6303; 0143-9266; 52584-286; 43066-027; 65372-1159; 70069-062; 17478-082; 65145-110; 0409-9303; 61876-0071; 55150-200; 70069-065; 70069-066; 70069-067
Synonyms Ropivacaine | 1-Propyl-2',6'-pipecoloxylidide | 1 Propyl 2',6' pipecoloxylidide | Naropin | Ropivacaine Monohydrochloride | Ropivacaine Hydrochloride | AL 381 | AL-381 | AL381 | Naropeine | LEA 103 | LEA-103 | LEA103 | Ropivacaine Monohydrochloride, (S)-isomer
Chemical Information
Molecular Formula C17H27ClN2O
CAS Registry Number 98717-15-8
SMILES CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Nightmare19.02.03.003--Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Oliguria20.01.03.004--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Paresis17.01.04.008--Not Available
Phlebitis12.02.01.002; 24.05.03.001--
Pleural effusion22.05.02.002--
Pneumothorax22.05.02.003--
Postpartum haemorrhage24.07.03.003; 18.06.01.001--Not Available
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.007--
Proctalgia07.03.02.001--
Prolonged labour18.07.01.001--Not Available
Prothrombin level decreased13.01.02.010--Not Available
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Purpura23.06.01.004; 01.01.04.003; 24.07.06.005--
Pyrexia08.05.02.003--
Pyuria20.02.01.012; 11.01.08.043--Not Available
Rales22.02.04.004--Not Available
Rash23.03.13.001--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression17.02.05.047; 22.02.01.010--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Respiratory paralysis22.02.06.003; 17.01.04.010--Not Available
The 5th Page    First    Pre   5 6 7 8    Next   Last    Total 8 Pages