Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rivaroxaban
Drug ID BADD_D01954
Description Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Indications and Usage Not Available
Marketing Status Prescription
ATC Code B01AF01
DrugBank ID DB06228
KEGG ID D07086
MeSH ID D000069552
PubChem ID 9875401
TTD Drug ID D0KG3R
NDC Product Code 50090-3625; 50458-579; 50458-575; 65015-898; 58032-2029; 55154-1424; 53296-0109; 14799-2023; 55111-966; 76072-1008; 47848-039; 55154-1423; 14501-0079; 65727-050; 52286-0025; 59285-009; 65862-971; 16436-0109; 75945-050; 50090-4468; 53104-7730; 50090-3639; 53747-068; 66022-0203; 50090-4469; 50458-580; 64220-176; 63415-0523; 64552-4049; 50458-578; 46708-899; 82513-0001; 66174-0087; 72969-109; 66039-913; 50458-584; 65372-1193; 50458-577; 55154-1422; 69218-0500
Synonyms Rivaroxaban | 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide | Xarelto | BAY 59-7939 | BAY 59 7939 | BAY 597939
Chemical Information
Molecular Formula C19H18ClN3O5S
CAS Registry Number 366789-02-8
SMILES C1COCC(=O)N1C2=CC=C(C=C2)N3CC(OC3=O)CNC(=O)C4=CC=C(S4)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Brain herniation12.01.10.001; 17.11.01.0020.001723%Not Available
Brain stem haemorrhage24.07.04.015; 17.08.01.0310.001164%Not Available
Brain stem infarction24.04.06.014; 17.08.01.0240.002677%Not Available
Breast cancer16.10.01.001; 21.05.01.003--Not Available
Breast mass21.05.04.002--Not Available
Breast swelling21.05.05.008--Not Available
Breast tenderness21.05.05.004--Not Available
Bronchiectasis22.03.02.005--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Bursitis15.04.01.001--Not Available
C-reactive protein increased13.09.01.007--Not Available
Cachexia14.03.02.001; 08.01.01.009; 16.32.03.011--Not Available
Calcinosis08.03.04.0020.000357%Not Available
Calculus urinary20.04.02.001--Not Available
Capillary fragility24.03.02.001; 23.06.04.0020.000357%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure acute02.05.01.0050.000745%Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cardiac murmur13.14.01.001--Not Available
Cardiac tamponade02.06.01.0010.012493%
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiogenic shock24.06.02.006; 02.05.01.003--Not Available
Cardiomegaly02.04.02.001--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Carotid artery stenosis17.08.02.001; 24.04.06.0010.001606%Not Available
Carotid artery thrombosis24.01.04.007; 17.08.01.0250.002499%Not Available
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