Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ramelteon
Drug ID BADD_D01908
Description Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Indications and Usage For the treatment of insomnia characterized by difficulty with sleep onset.
Marketing Status Prescription
ATC Code N05CH02
DrugBank ID DB00980
KEGG ID D02689
MeSH ID C495910
PubChem ID 208902
TTD Drug ID D0U0KW
NDC Product Code 55700-874; 0832-1250; 76397-021; 42413-0180; 58159-050; 0591-2191; 52817-235; 71205-918; 72189-153; 72319-005; 43598-741; 63190-0700; 70010-028; 51407-375; 50268-708; 73435-003; 66332-0014; 59651-469; 14501-0030; 63415-0150; 71335-1853; 63629-8264; 42291-776; 70710-1344; 70771-1495; 64764-805; 63629-8531
Synonyms ramelteon | (S)-N-(2-(1,6,7,8-tetrahydro-2H-indeno-(5,4)furan-8-yl)ethyl)propionamide | TAK-375 | Rozerem
Chemical Information
Molecular Formula C16H21NO2
CAS Registry Number 196597-26-9
SMILES CCC(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Altered state of consciousness19.07.01.003; 17.02.04.0010.006806%Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.017393%
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Blood cortisol decreased13.10.09.004--Not Available
Blood pressure increased13.14.03.0050.017393%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.004537%Not Available
Death08.04.01.001--
Delirium19.13.02.0010.052179%
Depression19.15.01.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.026089%
Drug hypersensitivity10.01.01.001--Not Available
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspnoea22.02.01.004; 02.01.03.002--
Eating disorder19.09.01.008; 14.03.01.0080.017393%Not Available
Epilepsy17.12.03.0020.026089%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.017393%Not Available
Gait disturbance08.01.02.002; 17.02.05.0160.017393%
Hallucination19.10.02.0020.026089%
Hangover08.01.09.0180.017393%Not Available
Headache17.14.01.0010.026089%
Heart rate decreased13.14.04.0010.017393%Not Available
Hepatic failure09.01.03.0020.004537%
Hepatic function abnormal09.01.02.0010.026089%Not Available
Hypersomnia19.02.05.001; 17.15.01.0010.017393%
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