| Pharmaceutical Information |
| Drug Name |
Protirelin |
| Drug ID |
BADD_D01871 |
| Description |
Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). It is a tri-peptide tropic hormone, released by the hypothalamus, that stimulates the release of Thyroid Stimulating Hormone (TSH) and prolactin from the anterior pituitary.
Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary hypothyroidism and acromegaly. |
| Indications and Usage |
|
| Marketing Status |
Discontinued |
| ATC Code |
V04CJ02 |
| DrugBank ID |
DB09421
|
| KEGG ID |
D00176
|
| MeSH ID |
D013973
|
| PubChem ID |
638678
|
| TTD Drug ID |
D08BTB
|
| NDC Product Code |
72969-111 |
| Synonyms |
Thyrotropin-Releasing Hormone | Thyrotropin Releasing Hormone | Thyrotropin-Releasing Factor | Thyrotropin Releasing Factor | Protirelin | Antepan | Protirelin Tartrate (1:1) | Proterelin Tartrate | Thyrotropin-Releasing Hormone Tartrate | Thyrotropin Releasing Hormone Tartrate | Relefact TRH | TRH, Relefact | Thypinone | Thyroliberin | Thyroliberin TRH Merck | TRH Prem | Prem, TRH | Proterelin Tartrate Hydrate | Hydrate, Proterelin Tartrate | Tartrate Hydrate, Proterelin | Abbott-38579 | Abbott 38579 | Abbott38579 | Stimu-TSH | Stimu TSH | StimuTSH | TRH Ferring |
|
| Chemical Information |
| Molecular Formula |
C16H22N6O4 |
| CAS Registry Number |
24305-27-9 |
| SMILES |
C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
|
|
