Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Primidone
Drug ID BADD_D01840
Description Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures.[L11112] Primidone was developed by J Yule Bogue and H C Carrington in 1949.[A189522] Primidone was granted FDA Approval on 8 March 1954.[L11112]
Indications and Usage For the treatment of epilepsy
Marketing Status Prescription; Discontinued
ATC Code N03AA03
DrugBank ID DB00794
KEGG ID D00474
MeSH ID D011324
PubChem ID 4909
TTD Drug ID D0U5RT
NDC Product Code 68084-202; 71610-079; 59348-0001; 72789-178; 63629-7811; 71610-191; 72789-177; 66490-691; 0615-8206; 65162-545; 17205-308; 71610-540; 71610-590; 0527-1301; 65162-544; 17205-307; 68682-690; 71610-005; 50090-1622; 55111-477; 53746-544; 42291-509; 50268-687; 0527-1231; 69584-685; 0904-5559; 72189-216; 69575-4045; 55111-876; 69584-684; 50268-686; 55111-476; 42291-511; 68084-203; 53746-545; 71335-1158; 68682-691; 0591-5321; 51927-2339; 10135-522; 66490-690; 71335-1965; 50090-4083; 49452-6020; 10135-540
Synonyms Primidone | Liskantin | Mylepsinum | Resimatil | Desoxyphenobarbital | Mizodin | Mysoline | Apo-Primidone | Apo Primidone | Primaclone | Sertan | Misodine | Primidon Holsten
Chemical Information
Molecular Formula C12H14N2O2
CAS Registry Number 125-33-7
SMILES CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Hepatic cirrhosisAlanine aminotransferase 1P24298Not Available3997653; 7118708; 6698876
Hepatic cirrhosisAlanine aminotransferase 1P24298Not Available6648747; 6518350; 3510392; 7049029
JaundiceAlanine aminotransferase 1P24298Not Available6648747; 6518350; 3510392; 7049029
JaundiceGlutathione hydrolase 7Q9UJ14T251226648747; 6518350; 3510392; 7049029
JaundiceAlkaline phosphatase, tissue-nonspecific isozymeP05186T095386648747; 6518350; 3510392; 7049029
JaundiceAlanine aminotransferase 1P24298Not Available3997653; 7118708; 6698876
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agranulocytosis01.02.03.001--Not Available
Anaemia01.03.02.001--
Anaemia megaloblastic14.12.01.003; 01.03.02.003--Not Available
Apathy19.04.04.002--Not Available
Aplasia08.03.04.003; 03.02.01.002--Not Available
Aplasia pure red cell10.02.01.003; 01.03.03.001--Not Available
Arteriovenous fistula24.03.03.0010.002319%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.0010.002319%Not Available
Ataxia17.02.02.001; 08.01.02.004--
Completed suicide19.12.01.001; 08.04.01.0100.000605%Not Available
Depressed level of consciousness17.02.04.0020.001546%
Depression19.15.01.0010.002319%
Dermatitis23.03.04.002--Not Available
Diplopia17.17.01.005; 06.02.06.002--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001546%
Drug hypersensitivity10.01.01.0010.003092%Not Available
Dupuytren's contracture15.03.03.0030.003092%Not Available
Emotional disorder19.04.02.005--Not Available
Eye disorder06.08.03.001--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.001546%Not Available
Flat affect19.04.01.004--Not Available
Gamma-glutamyltransferase increased13.03.01.0110.002319%
Gastrointestinal disorder07.11.01.001--Not Available
Granulocytopenia01.02.03.003--Not Available
Headache17.14.01.001--
Irritability19.04.02.013; 08.01.03.011--
Malaise08.01.01.0030.001546%
Nausea07.01.07.0010.001546%
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