Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Prilocaine
Drug ID BADD_D01836
Description A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)
Indications and Usage Used as a local anaesthetic and is often used in dentistry.
Marketing Status Prescription; Discontinued
ATC Code N01BB04
DrugBank ID DB00750
KEGG ID D00553
MeSH ID D011318
PubChem ID 4906
TTD Drug ID D06LYG
NDC Product Code 17381-017; 22365-119; 73309-214; 24196-186; 49452-6011; 53335-0004; 59014-0052; 69617-011
Synonyms Prilocaine | Propitocaine | Citanest Octapressin | Xylonest | Citanest | Prilocaine Hydrochloride
Chemical Information
Molecular Formula C13H20N2O
CAS Registry Number 721-50-6
SMILES CCCNC(C)C(=O)NC1=CC=CC=C1C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypotension24.06.03.002--
Hypoxia22.02.02.003--
Injury12.01.08.004--Not Available
Loss of consciousness17.02.04.004--Not Available
Muscle twitching15.05.03.005--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neurotoxicity17.02.10.002; 12.03.01.011--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Osteoarthritis15.01.04.001--Not Available
Oxygen saturation decreased13.02.01.004--Not Available
Pain08.01.08.004--
Paraesthesia17.02.06.005--
Paralysis17.01.04.004--Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression22.02.01.010; 17.02.05.047--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Sensory loss17.02.07.007--Not Available
Shock24.06.02.002--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Swelling08.01.03.015--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tension19.06.02.005--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
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