Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Prednisolone acetate
Drug ID BADD_D01832
Description Prednisolone acetate is a [prednisolone] molecule bound to an acetate functional group by an ester bond.[L9449] Prednisolone acetate was granted FDA approval in 1955.[L9449]
Indications and Usage For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.
Marketing Status Prescription; Discontinued
ATC Code A07EA01; C05AA04; D07AA03; D07XA02; H02AB06; R01AD02; S01BA04; S01CB02; S02BA03; S03BA02
DrugBank ID DB15566
KEGG ID D00980
MeSH ID C009935
PubChem ID 5834
TTD Drug ID Not Available
NDC Product Code 62991-1692; 82298-108; 22552-0044; 52128-150; 46439-8761; 11980-180; 11980-174; 50396-7014; 64958-0048; 50090-0561; 38779-0152; 51552-0027; 61314-637; 60722-3006; 60722-2005; 76420-204; 49452-5990; 50090-5275; 72189-055; 68071-2222; 82298-107; 60758-119; 51672-1338; 50090-1912; 50090-0559
Synonyms prednisolone acetate | prednisolone 21-acetate | pred forte | Scherisolone-Kristall suspension
Chemical Information
Molecular Formula C23H30O6
CAS Registry Number 52-21-1
SMILES CC(=O)OCC(=O)C1(CCC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye irritation06.04.05.0030.084738%Not Available
Eye pain06.08.03.0020.069046%
Eye swelling06.08.03.0030.028246%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.0020.006277%Not Available
Fat embolism24.01.01.012; 12.01.08.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Foreign body in eye12.01.04.012; 06.11.01.0050.015692%Not Available
Glaucoma06.03.01.0020.018831%
Glucose tolerance impaired14.06.02.001; 05.06.02.001--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatomegaly09.01.05.001--Not Available
Hiccups22.02.04.002; 07.01.06.009--
Hirsutism23.02.04.001; 05.05.01.005--
Hyperadrenocorticism24.08.02.005; 14.11.01.009; 05.01.01.003--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.0030.009415%
Hypertension24.08.02.001--
Hypertrophic cardiomyopathy03.07.02.004; 02.04.01.002--Not Available
Hypokalaemic syndrome14.05.03.003--Not Available
Hypopituitarism05.03.02.001--
Hypopyon11.01.06.009; 06.04.10.0040.009415%Not Available
Impaired healing08.03.02.001--Not Available
Increased appetite14.03.01.003; 08.01.09.027--Not Available
Increased insulin requirement05.06.01.006; 14.06.01.006--Not Available
Injury12.01.08.004--Not Available
Insomnia19.02.01.002; 17.15.03.002--
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