Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Prednisolone
Drug ID BADD_D01831
Description Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.[A187463] Prednisolone was granted FDA approval on 21 June 1955.[L9431]
Indications and Usage For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.
Marketing Status Prescription; Discontinued
ATC Code A07EA01; C05AA04; D07AA03; D07XA02; H02AB06; R01AD02; S01BA04; S01CB02; S02BA03; S03BA02
DrugBank ID DB00860
KEGG ID D00472
MeSH ID D011239
PubChem ID 5755
TTD Drug ID D0D1SG
NDC Product Code 0395-8164; 51927-0197; 22552-0052; 0527-5406; 82298-104; 50383-042; 64958-0097; 60592-911; 50090-0655; 63187-466; 65089-0038; 67296-1656; 23594-505; 51927-1148; 61919-291; 51927-0234; 57582-004; 38779-0150; 82298-106; 82298-105; 68788-9096; 60722-3001; 73534-505; 49452-5980
Synonyms Prednisolone | Predate | Predonine | Di-Adreson-F | Di Adreson F | DiAdresonF
Chemical Information
Molecular Formula C21H28O5
CAS Registry Number 50-24-8
SMILES CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
ApoptosisDNA topoisomerase 1P11387T098261374671; 1333943; 1333822; 1279323; 1338332; 1649059; 1997159; 1596908; 8383887; 8601414; 7596166; 8227159; 7641180; 10536167; 8319228; 14504478; 1319346; 1540962; 2168279; 7508535
Metabolic disorderCatenin beta-1P35222T8279526318657
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia17.02.06.005--
Paraparesis17.01.04.006--Not Available
Paraplegia17.01.04.007--Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006--Not Available
Peptic ulcer07.04.07.001--Not Available
Personality change19.05.01.006; 17.02.05.019--
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Rash23.03.13.001--Not Available
Secondary adrenocortical insufficiency14.11.01.014; 05.01.02.003--Not Available
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Skin atrophy23.01.05.001--
Skin striae23.01.05.002--Not Available
Sodium retention14.05.04.003--Not Available
Spinal compression fracture15.08.05.004; 14.04.04.003; 12.04.04.001--Not Available
Stress19.06.02.004--Not Available
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
Tachycardia02.03.02.007--Not Available
Tendon rupture15.07.01.008; 12.01.07.003--Not Available
Thrombophlebitis24.01.02.001--Not Available
Urticaria10.01.06.001; 23.04.02.001--
Vasculitis24.05.02.001; 10.02.02.006--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Weight increased13.15.01.006--
Oesophagitis ulcerative07.04.05.003--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
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