Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pravastatin sodium
Drug ID BADD_D01825
Description Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin].[T303] Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. Ltd.; however, the first approved pravastatin product was developed by Bristol Myers Squibb and FDA approved in 1991.[L6142] Pravastatin is made through a fermentation process in which [mevastatin] is first obtained. The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
Indications and Usage For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.
Marketing Status Prescription; Discontinued
ATC Code C10AA03
DrugBank ID DB00175
KEGG ID D00893
MeSH ID D017035
PubChem ID 16759173
TTD Drug ID D02RQU
NDC Product Code 50090-3258; 68180-487; 35356-919; 61919-801; 71205-516; 65862-635; 65862-633; 0615-8030; 50268-668; 70377-046; 68462-198; 68382-071; 68382-072; 63629-7086; 65841-739; 70377-048; 60687-169; 55154-7275; 60505-0170; 63629-8911; 70377-045; 63629-9162; 70518-1157; 68071-5001; 65862-634; 72189-060; 71335-0692; 0615-8410; 65862-632; 61919-731; 68071-3361; 0093-7202; 68462-197; 68180-485; 43063-143; 60505-1323; 60505-0168; 71610-637; 50090-4206; 68071-4707; 16729-009; 70518-2505; 70518-2887; 0904-5892; 50090-3853; 72189-059; 68180-488; 61919-708; 63629-9164; 68071-4039; 51079-458; 55154-5370; 50090-5927; 57237-165; 0904-5891; 50268-666; 55111-274; 0615-8029; 70934-161; 71205-294; 82009-007; 35356-921; 70934-832; 72789-143; 63187-415; 60687-190; 16729-011; 70518-2986; 71335-0947; 57237-167; 51846-1022; 16729-010; 55154-5365; 50268-665; 68071-3358; 35356-125; 58623-0123; 0093-7201; 60760-421; 82009-006; 68382-073; 63629-8910; 60505-0169; 63629-8904; 72789-161; 71335-1243; 55111-231; 60687-178; 63629-8905; 63629-8913; 68462-195; 68382-070; 61919-546; 61919-707; 50090-5809; 65841-740; 0093-0771; 63187-732; 42291-665; 55111-229; 51079-782; 72189-119; 50090-2024; 43353-964; 70377-047; 42291-669; 63629-7508; 72189-061; 70518-2229; 0904-5893; 68071-3247; 57237-166; 55111-230; 82009-008; 63629-8912; 50268-667; 68180-486; 70518-1938; 68462-196; 63629-8909; 71335-0056; 43063-443; 43063-807; 63629-9165; 65841-741; 16729-008; 0093-7270; 63629-8835; 65727-003; 71205-149; 68071-3366; 68254-0004; 60760-422; 63629-4588; 70518-0549; 63629-8836; 43063-808; 63629-8906; 70934-236; 70518-0876; 63187-413; 71335-0101; 61919-709; 63629-8833; 68071-5007; 57237-164; 42291-667; 50090-2025; 50090-3898; 65841-742; 43353-966; 55154-7998; 63629-9163; 71205-121; 43063-444; 68071-4894; 71335-1022; 50090-3204; 42291-668; 63187-731; 0615-8159
Synonyms Pravastatin | Eptastatin | Vasten | CS-514 | CS 514 | CS514 | Lin-Pravastatin | Lin Pravastatin | Lipemol | Liplat | Nu-Pravastatin | Nu Pravastatin | Prareduct | Mevalotin | Pravachol | Elisor | Selektine | Lipostat | Pravacol | Pravasin | Pravastatin Monosodium Salt, (6 beta)-Isomer | Pravastatin Sodium | Pravastatin Sodium Salt | Sodium Salt, Pravastatin | Pravastatin tert-Octylamine Salt | Pravastatin tert Octylamine Salt | Pravastatin, (6 beta)-Isomer | RMS-431 | RMS 431 | RMS431 | SQ-31000 | SQ 31000 | SQ31000 | SQ-31,000 | SQ 31,000 | SQ31,000 | Apo-Pravastatin | Apo Pravastatin | Bristacol
Chemical Information
Molecular Formula C23H35NaO7
CAS Registry Number 81131-70-6
SMILES CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Acute myocardial infarctionStromelysin-1P08254T86702Not Available
Angina pectorisStromelysin-1P08254T86702Not Available
AngioplastyStromelysin-1P08254T86702Not Available
ArteriosclerosisLiver carboxylesterase 1P23141T76369Not Available
Cerebrovascular accidentStromelysin-1P08254T86702Not Available
DeathStromelysin-1P08254T86702Not Available
Myocardial ischaemiaApolipoprotein EP02649T21689Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dysuria20.02.02.002--
Eosinophilia01.02.04.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gamma-glutamyltransferase increased13.03.01.011--
Gynaecomastia21.05.04.003; 05.05.02.003--
Haemolytic anaemia01.06.03.002--Not Available
Hair disorder23.02.06.003--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic necrosis09.01.07.002--
Hepatic steatosis14.08.04.005; 09.01.07.003--Not Available
Hepatitis09.01.07.004--Not Available
Hepatitis chronic active09.01.07.006; 11.07.01.002--Not Available
Hypersensitivity10.01.03.003--
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice cholestatic09.01.01.005--Not Available
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Malaise08.01.01.003--
Memory impairment19.20.01.003; 17.03.02.003--
Mucosal dryness08.01.06.001--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myopathy15.05.05.001--Not Available
The 2th Page    First    Pre   2 3 4    Next   Last    Total 4 Pages