Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Peramivir
Drug ID BADD_D01732
Description Peramivir is an antiviral agent developed by Biocryst Pharmaceuticals to treat influenza A/B. The development of peramivir has been supported by the US Department of Health and Human Services as part of the government's effort to prepare for a flu pandemic. Being an influenza virus neuraminidase inhibitor, peramivir works by preventing new viruses from emerging from infected cells. Due to the poor oral bioavailability, the oral formulation of the drug was previously abandoned by Johnson and Johnson Company. The injectable intravenous formulation of peramivir was approved by the FDA in September 2017 for the treatment of acute uncomplicated influenza to pediatric patients 2 years and older who have been symptomatic for no more than two days.
Indications and Usage Investigated for use/treatment in influenza.
Marketing Status Prescription
ATC Code J05AH03
DrugBank ID DB06614
KEGG ID D03829
MeSH ID C414210
PubChem ID 154234
TTD Drug ID D0P2IW
NDC Product Code 58159-052; 63552-077; 72769-181; 0792-0636
Synonyms peramivir | (1S,2S,3R,4R)-3-((1S)-1-acetamido-2-ethylbutyl)-4-((amino(imino)methyl)amino)-2-hydroxycyclopentanecarboxylic acid trihydrate | peramivir trihydrate | 3-(1'-acetylamino-2'-ethyl)butyl-4-((aminoimino)methyl)amino-2-hydroxycyclopentane-1-carboxylic acid | BCX 1812 | BCX1812 | BCX-1812 | RWJ 270201 | RWJ270201 | RWJ-270201 | Rapivab
Chemical Information
Molecular Formula C15H28N4O4
CAS Registry Number 330600-85-6
SMILES CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alanine aminotransferase13.03.01.031--Not Available
Aspartate aminotransferase increased13.03.01.006--
Blood creatine phosphokinase13.04.01.009--Not Available
Blood glucose13.02.02.009--Not Available
Constipation07.02.02.001--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Hallucination19.10.02.002--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Insomnia19.02.01.002; 17.15.03.002--
Neutrophil count13.01.06.046--Not Available
Rash23.03.13.001--Not Available
Skin reaction23.03.03.013; 10.01.03.019--Not Available
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Abnormal behaviour19.01.01.001--Not Available
Neuropsychiatric syndrome19.07.03.009; 17.02.10.014--Not Available
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