Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Blood creatine phosphokinase
ADR ID BADD_A00533
ADR Hierarchy
13      Investigations
13.04      Enzyme investigations NEC
13.04.01      Skeletal and cardiac muscle analyses
13.04.01.009      Blood creatine phosphokinase
Description A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. [MeSH]
MedDRA Code 10005467
MeSH ID D003402
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Blood creatine phosphokinase | CK | CPK | Creatine kinase | Creatine phosphokinase | Plasma creatine phosphokinase | Serum creatine phosphokinase | Creatine Kinase | Kinase, Creatine | ATP Creatine Phosphotransferase | Creatine Phosphotransferase, ATP | Phosphotransferase, ATP Creatine | Creatine Phosphokinase | Phosphokinase, Creatine | ADP Phosphocreatine Phosphotransferase | Phosphocreatine Phosphotransferase, ADP | Phosphotransferase, ADP Phosphocreatine | Macro-Creatine Kinase | Macro Creatine Kinase
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00085Alprazolam0.000251%
BADD_D00503Clonidine hydrochloride--
BADD_D00512Cobicistat--
BADD_D00704Dolutegravir sodium--
BADD_D00707Donepezil hydrochloride--
BADD_D00735Duloxetine hydrochloride--
BADD_D00756Eletriptan hydrobromide--
BADD_D00762Elvitegravir--
BADD_D00766Emtricitabine--
BADD_D00771Enfuvirtide--
BADD_D01352Maraviroc--
BADD_D01550Nelfinavir mesylate--
BADD_D01732Peramivir--
BADD_D01971Rosuvastatin0.000088%
BADD_D02101Sunitinib malate--
BADD_D02156Tenofovir disoproxil fumarate--
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