Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penicillamine
Drug ID BADD_D01709
Description Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an α-amino acid metabolite of penicillin, although it has no antibiotic properties.
Indications and Usage For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis.
Marketing Status Prescription; Discontinued
ATC Code M01CC01
DrugBank ID DB00859
KEGG ID D00496
MeSH ID D010396
PubChem ID 5852
TTD Drug ID D08HZC
NDC Product Code 0591-4171; 68022-7041; 76003-0870; 0395-8148; 51991-974; 25010-705; 49884-146; 0037-4401; 42973-230; 71052-491; 51552-1096; 43598-634; 76339-159; 43975-309; 60505-4696; 59285-014; 70748-153; 62207-013; 71205-916; 68475-201; 70010-907; 59651-245; 62559-970; 0254-2000; 38779-0244; 72640-012; 70159-004; 68682-020
Synonyms Penicillamine | Mercaptovaline | D-Penicillamine | D Penicillamine | Dimethylcysteine | beta,beta-Dimethylcysteine | beta,beta Dimethylcysteine | D-3-Mercaptovaline | D 3 Mercaptovaline | Metalcaptase | Cuprimine | Copper Penicillaminate | Penicillaminate, Copper | Cuprenil
Chemical Information
Molecular Formula C5H11NO2S
CAS Registry Number 771431-20-0
SMILES CC(C)(C(C(=O)O)N)S
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Congenital, familial and genetic disordersCollagen alpha-1(I) chainP02452Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Congenital, familial and genetic disordersElastinP15502Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Cutis laxaElastinP15502Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Cutis laxaCollagen alpha-1(I) chainP02452Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
DermatomyositisHLA-DR4 proteinO77963Not Available1411195; 3501473; 8403583; 3134689; 94219; 6658398; 6305039; 3492852; 3738397; 6334465; 3707633; 3929421; 1604135; 4018948; 3704516; 3437418; 843119; 7697959
DermatomyositisMHC class I antigenO19755Not Available1411195; 3501473; 8403583; 3134689; 94219; 6658398; 6305039; 3492852; 3738397; 6334465; 3707633; 3929421; 1604135; 4018948; 3704516; 3437418; 843119; 7697959
DermatomyositisMHC class I antigen HLA-B18O77967Not Available1411195; 3501473; 8403583; 3134689; 94219; 6658398; 6305039; 3492852; 3738397; 6334465; 3707633; 3929421; 1604135; 4018948; 3704516; 3437418; 843119; 7697959
Elastosis perforansElastinP15502Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Elastosis perforansCollagen alpha-1(I) chainP02452Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Impaired healingCollagen alpha-1(I) chainP02452Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Impaired healingElastinP15502Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
PolymyositisHLA class II histocompatibility antigen, DRB1 beta chainP01911Not Available4018948; 3133153; 6605118; 3415364
Skin fragilityElastinP15502Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Skin fragilityCollagen alpha-1(I) chainP02452Not Available3063003; 6216862; 7068961; 7282106; 3319968; 6939876; 7362666; 16144289; 6439866; 1536698; 8912569; 6658398; 4018948; 10352832; 3459889; 3213269; 3707633; 2082056; 8045756
Skin toxicityHLA-DRB3*02.01 class II antigen beta III (DRw6b)Q6LBW5Not Available3133153; 6770269; 3157529; 6439866; 3133152; 6376799; 3437418; 8151585; 3492038; 6959574; 6234391; 6402993; 3482988; 2570550; 6420562; 3487119; 8846545
Toxicity to various agentsHLA class II histocompatibility antigen, DRB1 beta chainP01911Not Available4018948; 3133153; 6605118; 3415364
Toxicity to various agentsHLA class II histocompatibility antigen, DR beta 5 chainQ30154Not AvailableNot Available
Toxicity to various agentsHLA class I histocompatibility antigen, B alpha chainP01889Not AvailableNot Available
Toxicity to various agentsHLA-DR3Q29887Not AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Lichen planus23.03.08.001--Not Available
Lymphadenopathy01.09.01.002--Not Available
Monocytosis01.02.01.004--Not Available
Motor neurone disease17.05.05.002--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myasthenia gravis15.05.08.001; 17.05.04.001; 10.04.05.0010.000240%
Nausea07.01.07.001--
Nephrotic syndrome20.05.01.002--
Neuropathy peripheral17.09.03.003--Not Available
Obliterative bronchiolitis22.03.01.012--Not Available
Optic neuritis17.04.05.001; 10.04.10.002; 06.04.08.002--Not Available
Pancreatitis07.18.01.001--
Pancytopenia01.03.03.003--Not Available
Papule23.03.03.038--Not Available
Pemphigoid23.03.01.004; 10.04.02.002--Not Available
Pemphigus23.03.01.005; 10.04.02.003--Not Available
Peptic ulcer07.04.07.001--Not Available
Peripheral sensory neuropathy17.09.03.005--
Polymyositis10.04.05.004; 15.05.01.004--Not Available
Proteinuria20.02.01.011--
Pulmonary fibrosis22.01.02.006--
Rash23.03.13.0010.000240%Not Available
Rash erythematous23.03.06.003--Not Available
Renal failure20.01.03.005--Not Available
Renal vasculitis20.01.07.007; 10.02.02.013; 24.05.02.007--Not Available
Sideroblastic anaemia01.03.02.009--Not Available
Skin disorder23.03.03.0070.000240%Not Available
Skin hyperpigmentation23.05.01.0030.000240%
Skin wrinkling23.01.03.001--Not Available
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