Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Penciclovir
Drug ID BADD_D01708
Description Penciclovir is a synthetic acyclic guanine derivative with antiviral activity used for the treatment of various herpes simplex virus (HSV) infections. Displaying low toxicity and good selectivity, penciclovir is a nucleoside analogue.
Indications and Usage Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.
Marketing Status Prescription
ATC Code D06BB06; J05AB13
DrugBank ID DB00299
KEGG ID D05407
MeSH ID C053539
PubChem ID 135398748
TTD Drug ID D07BYK
NDC Product Code 67835-0010; 69875-8004; 0378-9720; 29902-0021; 70600-022; 65015-899; 63310-2500; 46708-932
Synonyms penciclovir | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine | penciclovir, monosodium salt | BRL 39123 | BRL-39123 | Penciclovir Visfarm | Denavir | Vectavir | penciclovir, monosodium salt, monohydrate
Chemical Information
Molecular Formula C10H15N5O3
CAS Registry Number 39809-25-1
SMILES C1=NC2=C(N1CCC(CO)CO)N=C(NC2=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Migraine24.03.05.003; 17.14.02.001--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.004--Not Available
Oropharyngeal swelling22.04.05.005; 10.01.05.014; 07.05.04.002; 23.04.01.013--Not Available
Pain08.01.08.004--
Palpitations02.01.02.003--
Paraesthesia17.02.06.005--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Pharyngeal oedema22.04.05.003; 10.01.05.016; 23.04.01.016--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash erythematous23.03.06.003--Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome10.01.03.020; 23.03.01.007; 12.03.01.014; 11.07.01.005--
Therapeutic response decreased08.06.01.016--Not Available
Thrombocytopenia01.08.01.002--Not Available
Toxic epidermal necrolysis12.03.01.015; 11.07.01.006; 10.01.01.006; 23.03.01.008--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
Localised oedema14.05.06.009; 08.01.07.011; 02.05.04.006--
Lymphatic disorder01.09.01.003--Not Available
Cardiac disorder02.01.01.003--Not Available
Mental disorder19.07.01.002--Not Available
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Oral herpes11.05.02.005; 07.05.07.002--Not Available
Acute kidney injury20.01.03.016--
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