Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status approved; investigational
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
UNII 2H1PA8H1EN
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry eye06.08.02.001--
Dyspepsia07.01.02.001--
Ear disorder04.03.01.001--Not Available
Ectropion23.07.05.001; 06.06.04.001--Not Available
Eczema23.03.04.006--
Endophthalmitis11.01.06.003; 06.04.05.009--
Exostosis15.02.04.005--
Eye discharge06.04.05.001--Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage12.02.02.012; 24.07.05.002; 06.07.02.001--Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.002--
Eye swelling06.08.03.003--Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.002--
Gastrointestinal disorder07.11.01.001--Not Available
Hair colour changes23.02.06.001--
Headache17.14.01.001--
Hypertension24.08.02.001--
Hyphaema24.07.05.004; 12.01.04.007; 06.07.04.001--Not Available
Hypotony of eye06.08.03.004--Not Available
Immune system disorder10.02.01.001--Not Available
Influenza like illness08.01.03.010--
Injection site reaction12.07.03.015; 08.02.03.014--
Injection site vesicles12.07.03.051; 08.02.03.051; 23.03.01.024--Not Available
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