Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Rash papular23.03.13.017--Not Available
Rash pruritic23.03.13.030--Not Available
Rash vesicular23.03.13.009--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.0010.000918%
Renal cancer20.01.04.002; 16.08.02.0010.003380%Not Available
Renal failure20.01.03.0050.002574%Not Available
Renal haemorrhage24.07.07.002; 20.01.02.013; 12.01.05.0040.000224%
Renal infarct24.01.11.004; 20.01.07.0080.000112%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.001567%
Restrictive cardiomyopathy02.04.01.005--
Retching07.01.07.0020.000604%Not Available
Retinal detachment12.01.04.004; 06.09.03.0030.000448%
Retinal disorder06.08.03.0050.000246%Not Available
Retinal tear12.01.04.014; 06.09.03.0100.000448%
Retinal vein occlusion24.01.07.006; 06.10.01.0100.000112%Not Available
Retroperitoneal haemorrhage12.01.17.018; 24.07.01.017; 07.07.02.002--
Rhinorrhoea22.12.03.0210.001589%
Sarcoma15.09.03.002; 16.33.01.0020.000560%Not Available
Sarcoma uterus16.33.01.001; 21.07.02.0050.000168%Not Available
Sciatica17.10.03.001; 15.10.01.0010.000112%Not Available
Second primary malignancy16.16.01.0140.001063%
Shock24.06.02.002--Not Available
Sinus bradycardia02.03.03.009--
Sjogren's syndrome15.06.01.015; 10.04.04.009; 07.06.01.010; 06.08.02.0110.000112%Not Available
Skin depigmentation23.05.02.0020.001780%Not Available
Skin discolouration23.03.03.0050.007275%Not Available
Skin disorder23.03.03.0070.000795%Not Available
Skin exfoliation23.03.07.0030.002518%Not Available
Skin fissures23.03.03.0080.000492%Not Available
Skin hyperpigmentation23.05.01.0030.000571%
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