Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Restrictive cardiomyopathy
ADR ID BADD_A03826
ADR Hierarchy
02      Cardiac disorders
02.04      Myocardial disorders
02.04.01      Cardiomyopathies
02.04.01.005      Restrictive cardiomyopathy
Description A disorder characterized by an inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and loses its flexibility. [CTCAE] A form of CARDIAC MUSCLE disease in which the ventricular walls are excessively rigid, impeding ventricular filling. It is marked by reduced diastolic volume of either or both ventricles but normal or nearly normal systolic function. It may be idiopathic or associated with other diseases (ENDOMYOCARDIAL FIBROSIS or AMYLOIDOSIS) causing interstitial fibrosis. [MeSH]
MedDRA Code 10038748
MeSH ID D002313; D004719; D002313
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Endomyocardial fibrosis | Eosinophilic endomyocardial disease | Obliterative cardiomyopathy | Restrictive cardiomyopathy | Cardiomyopathy, Restrictive | Cardiomyopathies, Restrictive | Restrictive Cardiomyopathies | Restrictive Cardiomyopathy | Familial Restrictive Cardiomyopathy
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00318Busulfan--
BADD_D00349Capecitabine0.000139%
BADD_D00440Chloroquine0.001864%
BADD_D00697Dobutamine0.000371%
BADD_D01136Imatinib0.000533%
BADD_D01431Methylphenidate0.000184%
BADD_D01687Pazopanib--
BADD_D01834Prednisone0.000016%
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