Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Optimark
Drug ID BADD_D01621
Description Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.
Indications and Usage Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.
Marketing Status Prescription
ATC Code V08CA06
DrugBank ID DB00538
KEGG ID D01646
MeSH ID C112666
PubChem ID 6435809
TTD Drug ID D0X0GI
NDC Product Code Not Available
Synonyms gadoversetamide | OptiMARK
Chemical Information
Molecular Formula C20H34GdN5O10
CAS Registry Number 131069-91-5
SMILES COCCNC(=O)CN(CCN(CCN(CC(=O)NCCOC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].[Gd+3]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eye pain06.08.03.002--
Face oedema08.01.07.003; 23.04.01.004; 10.01.05.002--
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Feeling hot08.01.09.009--Not Available
Flatulence07.01.04.002--
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Gastric ulcer07.04.03.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Gastrointestinal perforation07.04.04.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Haemoglobin13.01.05.018--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Hair disorder23.02.06.003--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Herpes simplex11.05.02.001; 23.09.03.001--Not Available
Hyperacusis17.04.03.003; 04.02.02.001--Not Available
Hypercalcaemia14.04.01.003; 05.04.01.002--
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypoaesthesia17.02.06.023--Not Available
Hypocalcaemia14.04.01.004--
Hypoglycaemia14.06.03.001; 05.06.03.001--
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