Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Ofloxacin
Drug ID BADD_D01598
Description A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.
Indications and Usage For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea.
Marketing Status approved
ATC Code J01MA01; S01AE01; S02AA16
DrugBank ID DB01165
KEGG ID D00453
MeSH ID D015242
PubChem ID 4583
TTD Drug ID D03NHW
NDC Product Code 13985-602; 17478-713; 24208-410; 60505-0560; 63187-472; 63187-734; 0404-7189; 68071-2265; 68788-8195; 70756-607; 75834-119; 11980-779; 53002-1604; 53002-2604; 50090-5186; 60505-0363; 70518-2037; 71209-099; 70518-0192; 70518-3573; 59116-1820; 68788-8178; 70518-3710; 71205-420; 53069-0440; 53002-1324; 63187-184; 64980-432; 71209-097; 58032-0090; 24208-434; 68071-2254; 68071-2544; 68071-2834; 75834-112; 75834-120; 68071-3448; 68788-7693; 72189-108; 50090-1346; 63187-662; 64980-515; 63187-268; 63629-8716; 68788-8264; 68788-8449; 71209-098; 59390-140
UNII A4P49JAZ9H
Synonyms Ofloxacin | Ofloxacine | Tarivid | ORF-28489 | ORF 28489 | ORF28489 | DR-3355 | DR 3355 | DR3355 | Hoe-280 | Hoe 280 | Hoe280 | Ofloxacin Hydrochloride | Ru-43280 | Ru 43280 | Ru43280 | DL-8280 | DL 8280 | DL8280
Chemical Information
Molecular Formula C18H20FN3O4
CAS Registry Number 82419-36-1
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal discomfort15.03.04.001--Not Available
Affect lability19.04.01.001--Not Available
Haemorrhage24.07.01.002--Not Available
Temperature intolerance08.01.09.0220.000167%Not Available
Vasodilation procedure25.03.01.001--Not Available
Drug resistance08.06.01.0050.000083%Not Available
Urine output increased13.13.03.002--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Inflammation10.02.01.089; 08.01.05.007--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000083%
Ill-defined disorder08.01.03.049--Not Available
Sensation of foreign body08.01.09.002--Not Available
Artery dissection24.02.01.0030.000083%Not Available
Chondropathy15.07.03.0030.000083%Not Available
Psychotic disorder19.03.01.002--
Urethritis noninfective20.07.02.002--Not Available
Vulvovaginal mycotic infection21.14.02.004; 11.03.05.004--Not Available
Neuropsychological test abnormal13.07.06.001--Not Available
Bone marrow failure01.03.03.005--
Tendon pain15.07.01.0090.000333%Not Available
Psychiatric decompensation19.01.02.0100.000083%Not Available
Acute kidney injury20.01.03.0160.000250%
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.000208%Not Available
Language disorder19.19.01.006; 17.02.08.0150.000083%Not Available
Multiple organ dysfunction syndrome08.01.03.0570.000083%
Dermatitis exfoliative generalised23.03.07.002; 10.01.01.0290.000083%Not Available
Persecutory delusion19.10.01.0070.000083%Not Available
Weight bearing difficulty15.03.05.0340.000167%Not Available
Chemical burns of eye12.03.02.009; 06.11.01.013--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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