Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Nortriptyline hydrochloride
Drug ID BADD_D01589
Description Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Indications and Usage Primarily indicated for the relief of symptoms of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AA10
DrugBank ID DB00540
KEGG ID D00816
MeSH ID D009661
PubChem ID 441358
TTD Drug ID D04WFD
NDC Product Code 51672-4004; 60760-401; 51672-4001; 70771-1612; 70710-1156; 71335-0155; 50090-0507; 67544-078; 60760-508; 43063-897; 50090-1323; 63187-809; 0591-5787; 71335-1726; 55700-501; 68071-3232; 51927-0128; 49452-4858; 17337-0534; 0406-9912; 43063-722; 46438-0049; 0121-0678; 70518-1522; 68788-7216; 55700-668; 0406-9913; 68071-3211; 63187-759; 70518-1187; 62991-2905; 70710-1155; 0591-5789; 70518-0708; 63187-153; 50090-0537; 51862-948; 61919-510; 71335-1773; 51927-2175; 0093-0810; 61919-353; 70771-1613; 68071-3109; 72189-177; 66577-025; 71205-254; 58118-4002; 71335-1552; 51862-946; 0093-0812; 68788-8158; 0406-9910; 71335-0065; 71554-011; 63187-396; 51862-947; 60760-811; 0093-0813; 70771-1615; 70710-1153; 50268-605; 51862-945; 70518-0702; 60687-293; 70518-0741; 0591-5786; 54154-007; 51862-016; 0591-5788; 71335-0426; 50268-604; 51672-4002; 68071-2327; 60687-265; 51672-4003; 61919-590; 70710-1154; 50268-603; 0406-9911; 63187-227; 63187-798; 71335-1743; 60687-281; 63187-088; 63187-715; 70771-1614; 64330-018; 68788-9830; 71335-0083; 63629-3204; 0093-0811
Synonyms Nortriptyline | Desitriptyline | Desmethylamitriptylin | Allegron | Apo-Nortriptyline | Apo Nortriptyline | Aventyl | Gen-Nortriptyline | Gen Nortriptyline | Paxtibi | Nortrilen | Nortriptyline Hydrochloride | Hydrochloride, Nortriptyline | Novo-Nortriptyline | Novo Nortriptyline | Nu-Nortriptyline | Nu Nortriptyline | Pamelor | PMS-Nortriptyline | PMS Nortriptyline | ratio-Nortriptyline | ratio Nortriptyline | Norfenazin
Chemical Information
Molecular Formula C19H22ClN
CAS Registry Number 894-71-3
SMILES CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Generalised oedema08.01.07.004; 14.05.06.007--
Gynaecomastia21.05.04.003; 05.05.02.003--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertension24.08.02.001--
Hypoaesthesia17.02.06.023--Not Available
Hypomania19.16.02.001--Not Available
Hypotension24.06.03.002--
Ileus paralytic07.02.05.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice09.01.01.004; 01.06.04.004; 23.03.03.030--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased21.03.02.007; 19.08.03.002--
Malaise08.01.01.003--
Micturition disorder20.02.02.005--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neuropathy peripheral17.09.03.003--Not Available
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Palpitations02.01.02.003--
Panic reaction19.06.04.003--Not Available
Paraesthesia17.02.06.005--
Parotid gland enlargement07.06.03.001--Not Available
Petechiae24.07.06.004; 23.06.01.003; 01.01.03.002--Not Available
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